Year: 2002

How Cells Migrate in the Drosophila Ovary May Lead to a Better Understanding of Ovarian Cancer Metastasis

Ovarian cancer is thought to arise from cells of the surface epithelium of the ovary. However, most patients are diagnosed when the cancer has already spread beyond the ovaries. Such metastatic disease is rarely cured by current therapies…

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Defining Genetic Pathways that Underlie Ovarian Carcinogenesis Using Microarray Expressoin Analysis

Like all cancers, ovarian cancer is a genetic disease, which develops because of alterations in the genes that normally function to control cell division and tissue growth…

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Mechanisms of Gene Instability in Ovarian Cancer

PCNA is a protein that is involved in telling the cell not to divide if there is DNA damage within the cell…

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Identification of Novel Genetic Markers of Response to Imatinib Mesylate in Ovarian Carcinomas

The death rate from ovarian cancer is appallingly high. Most deaths occur because the tumor has spread from the ovary before detection of the disease…

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The Role of a Lipid Molecule in Promoting Ovarian Cancer Tumor Growth

Dr. Fang focuses on identifying and targeting small molecules that regulate the development and progression of ovarian cancer. Recently, Dr…

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Finding Genes Associated with Drug Resistance in Ovarian Cancer

Dr. Couch aims to develop a better understanding of the genetic events that cause resistance to taxol and platinum drugs, the standard chemotherapy combination treatment for ovarian cancer…

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Targeting Tumor Blood Vessel Growth Factors with Antibodies as a New Ovarian Cancer Treatment

The dissemination of cancer cells from the primary tumor to distant organs through the blood is a characteristic of cancer progression…

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Sensitization of Human Ovarian Cells to a Protein that Causes Cell Death

TRAIL is a membrane protein that can be released from cells and which induces a specific form of cell death, termed “apoptosis” in sensitive cells…

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