Year: 2003

Finding Biomarkers for Early Detection of Ovarian Cancer

The objective of the proposed study is to identify biomarkers that can be used for early detection of ovarian cancer and for assessing the efficacy of chemoprevention agents that could potentially stop the disease from occurring…

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Transgenic Approaches to Study Ovarian Cancer Prevention

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Trying to Understand the Mechanism for Cisplatin

While platinum agents, such as cisplatin, are the chemotherapeutic drugs of choice in the treatment of ovarian cancer, the majority of patients eventually develop drug resistance…

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Role of MAP2K4 Suppressing Metastasis of Serous Ovarian Cancers

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How Chemical Alterations to the DNA-but not its Sequence-May Play a Role in Ovarian Cancer

The molecular mechanisms involved in the development of ovarian cancer are poorly understood…

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A New Combination Drug Treatment for Ovarian Cancer

Despite the high initial response rates of patients with advanced ovarian cancer to aggressive primary surgical debulking followed by chemotherapy , the disease will recur in most patients…

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Gene Copy Number Alterations in Ovarian Cancer

Dr. Lucito aims to use an innovative method, called ROMA, that he developed to look at genetic alterations in the genome of ovarian cancer cells…

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Novel Approaches to the Androgen Pathway and Genetic Predisposition to Ovarian Cancer

Ovarian Cancer is the leading cause of death from gynecologic malignancies. Over the past decade we have learned much about the causes of hereditary ovarian cancer, but little is known regarding the genetic risk factors for sporadic ovarian cancer…

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Evaluation of Mesothelin as a Taret Antigen in Ovarian Cancer

Several lines of evidence suggest that the immune system may play an important role in ovarian cancer, including recent research showing that ovarian cancer patients with T lymphocytes infiltrating their tumor have a better prognosis than those…

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A Possible New Marker for Drug Resistance of Ovarian Cancer

For most ovarian cancer patients, a combination of surgery and postoperative chemotherapy is the standard of care. Chemotherapy consists of six cycles of Taxol and Carboplatin…

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Finding Molecules to Stop an Abnormal Signaling Pathway in Ovarian Cancer

The growth and survival of normal cells depends on the signaling molecule, AKT, a serine-threonine protein kinase. In ovarian cancer, however, AKT kinase activity is pathologically increased…

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Ovarian Cancer Biomarkers: Identification, Validation and Assessment of Biological Function

Dr. Drapkin is focused on developing methods for early screening and detection of ovarian cancer using biomarkers in blood serum. Serum biomarkers are very versatile tools…

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