Year: 2004

Immunotherapy of Ovarian Cancer Using Certain Tumor Specific Glycopeptides

To have an effective cancer vaccine, it is important to identify molecules on tumor cells that the human immune system can see as foreign (tumor antigens)…

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DNA Vaccines in Ovarian Cancer

Ovarian cancer poses a significant clinical challenge. Most women present with later stage disease for which there are no proven and reliable treatments…

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Understanding the Role of Tumor Blood Vessel Growth and Circulating Tumor DNA in Women with Ovarian Cancer

Ovarian cancer is unusual among intra-abdominal epithelial cancers in that it only rarely spreads through the bloodstream to different sites. More commonly, ovarian cancer spreads locally in the abdominal cavity. Recent work in Dr…

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Developing Drugs to Block Blood Vessel Growth in Ovarian Tumors

The growth and metastasis of ovarian cancer depends, in part, on formation of an adequate blood supply to transport needed oxygen and nutrients to the growing tumor mass…

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Biomarkers for Ovarian Cancer

Methods for early detection and/or prevention of the development of ovarian cancer are urgently required to improve the prognosis and overall survival of ovarian patients. Dr…

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Role and Regulation of Hepatocyte Growth Factor and c-Met in Ovarian Cancer

The dissemination of ovarian cancer cells throughout the abdominal cavity is reponsible for mortality in ovarian cancer patients…

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Another Protein Made by BRCA1 and its Role in Ovarian Cancer

In some families, ovarian cancer is caused by the inaction of the tumor-suppressor gene, BRCA1. Dr. El Shamy has has discovered a second protein produced at the BRCA1 gene location, named IRIS, the function of which is not known. But Dr…

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Phenotypic and Molecular Effects if Phosphoinositide 3-Kinase (PI3 Kinase)/Akt Pathway Activation in Mouse Ovary Using Conditional Deletion of Tumor Suppressor Gene PTEN

Cancer cells grow due to a range of different mechanisms such as, the over-expression of oncogenes, or genes that cause cancer, or the shutdown of genes encoding tumor suppressors, or genes that stop cancerous growth…

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Identification and Validation of Clinically Relevant Targets in Ovarian Tumore Vasculature

Tumor blood vessels are different than normal blood vessels. Tumor vessels not only function differently, they also make unique proteins not made by normal blood vessels…

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Depleting Regulatory T Cells to Treat Ovarian Cancer

In many ovarian cancer patients, initial response to chemotherapy is good and the tumor will shrink or go away…

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Novel Approaches to Ovarian Cancer Treatment

The Memorial Sloan-Kettering Cancer Center program in ovarian cancer plans to improve knowledge about ovarian cancer biology and translate the findings into better molecular therapeutics for women with the disease…

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Studying Membrane Proteins for Early Diagnosis and Disease Progression in Ovarian Cancer

Proteins on the surfaces of cell membranes move chemicals in and out of cells, transfer information between cells and their environment, and play crucial roles in many cellular and physiological processes. Dr…

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