Year: 2006

The Role of PIK3CA in Epithelial Ovarian Cancer

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Telomeres and Telomerase in Relation to Ovarian Cancer Risk

Telomeres are repeated DNA sequences that protect the ends of chromosomes. Telomeres shorten over time and ultimately signal cellular senescence…

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Understanding the Key Molecular Pathways that Drive Ovarian Cancer

For the past several decades, ovarian cancer research has identified many genetic alterations that allow ovarian cancer cells to grow and for tumors to resist chemotherapy…

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Gene May Be an Early Marker for Ovarian Cancer

Unfortunately, most ovarian cancer is detected too late and treatment options become limited. Therefore, a better understanding of early changes in ovarian cancer should allow early detection, better diagnosis and improved treatment. Dr…

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An Animal Model to Study Major Genetic Alterations in Ovarian Cancer

Most ovarian cancer detection occurs when the disease has spread and treatment options soon become limited…

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Method to Determine if a Male Hormone, Naturally Present in Woman, Affects the Risk of Developing Ovarian Cancer

Ovarian cancer is the leading cause of death from gynecologic malignancies…

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Clinical Implications of the TLR-4MYD88 Pathway in EOC

The combination of paclitaxel and carboplatin is the most commonly utilized combination chemotherapy in the treatment of primary epithelial ovarian cancers…

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Molecular Changes to DNA that Contribute to Ovarian Cancer

Ovarian cancer cells contain molecular changes that facilitate rapid and sustained cancer cell growth. Dr…

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Using Antibodies to Detect Early Ovarian Cancer

Ovarian cancer is a lethal disease that is commonly not detected until advanced stages when it is associated with poor survival…

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New Analytical Tool for Ovarian Cancer Detection

Most ovarian cancer detection occurs when the disease has spread and treatment options soon become limited…

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Ovarian Cancer Biomarkers: Identification, Validation and Assessment of Biological Function

Dr. Drapkin is focused on developing methods for early screening and detection of ovarian cancer using biomarkers in blood serum. Serum biomarkers are very versatile tools…

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Developing Mouse Models of Ovarian Cancer

Research in the laboratory of Dr. Connolly is aimed at the development, refinement and analysis of mouse models of epithelial ovarian cancer…

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