Year: 2007

Novel Animal Model to Test Drugs Against Ovarian Cancer

The goal of Dr. Zhang’s research is to validate a mouse model of ovarian cancer to be used to screen new drugs to fight ovarian cancer…

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BRCA/AKT1 Pathway in Ovarian Cancer

Mutations in the BRCA1 gene account for more than 30 percent of hereditary ovarian cancer and loss of BRCA1 expression has been shown in 30 percent to 60 percent of sporadic [or non-hereditary] ovarian cancers, the more common types of ovarian…

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How One Biological Pathway Running Amok in Ovarian Cells Contributes to Cancer

The biological functions of cells inside human body depend on the intricate networking of signaling pathways. Aberration of those signaling pathways has been linked to many diseases, including cancer. Dr…

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Understanding the Genetics of Metastasis May Help Prevent and Stop It

Unfortunately, most ovarian cancers are first diagnosed as advanced metastatic disease when the potential for a cure is slim. Dr…

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Enhancing Immunity to Ovarian Cancer Tumors

Ovarian cancer utilizes a number of strategies to evade attack from the immune system. The goal of Dr. Odunsi’s project is to harness the immune system to improve treatment of ovarian cancer patients…

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How Might Different Tissues in the Ovary Act on Each Other to Induce Cancer

The human ovary is covered by a single layer of epithelial cells. Beneath the epithelial cells is the ovarian cortical stroma. Fibroblasts are a major cell type in the ovarian stroma…

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MicroRNA’s as Diagnostic and Therapeutic Targets in Ovarian Cancer

Traditional genes account for only about 2% of all human genetic material. Until recently, it was believed that the remaining genetic material acted as a scaffold…

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Validation of a Human Ovarian Cancer Stem Cell Signature and its Use to Select Optimal Therapeutic Strategies for Ovarian Cancer Patients

One explanation as to why ovarian cancer cells metastasize and resist treatment is ovarian cancer stem cells. A property of stem cells is their ability to migrate from their site of origin and invade other tissues…

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A New Treatment that Aims to Stop Metastasis

Mesothelin is a protein that is highly prevalent in approximately 70 percent of ovarian cancers, making mesothelin a new target for anticancer agents…

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Testing New Therapeutic Agents to Treat Ovarian Cancer

Dr. Cheung is researching new types of drugs that are designed to deactivate two molecular pathways, called AKT and PAK, which are believed to make ovarian cancers particularly aggressive…

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Animal Model to Study Ovarian Cancer Stem Cells

The high rate of therapeutic failure and tumor relapse currently seen in ovarian cancer could result from ineffective targeting of ovarian cancer stem cells…

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Leading the Effort to Develop Vaccines and Immunotherapy for Ovarian Cancer

Dr…

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