Year: 2008

Cellular Microenvironment Role in Ovarian Cancer Development

The ovary is composed of an epithelium on its surface and a stroma-the inner mass consisting of several cell types. Interactions between these two compartments are crucial in epithelial ovarian cancer development…

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Characterizing the Genetic Alterations of Aggressive Ovarian Cancer

Recent advances in understanding ovarian cancer suggest that epithelial ovarian cancer can be classified into two groups: low-grade type I cancer which progress slowly from well-defined precursor lesions, and high-grade type II cancer which progress…

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The Carbohydrate Components of Cellular Molecules: A New Way to Diagnose Ovarian Cancer?

Earlier detection of ovarian cancer is the holy grail of ovarian cancer research. While many researchers focus on proteins and genes specific to ovarian cancer as possible diagnostic markers, Dr…

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Understanding the Molecular Pathways to Chemotherapy Resistance in Ovarian Cancer

Despite initial responses to surgery and chemotherapy, the majority of women with ovarian cancer ultimately die from recurrence and disease spread. Overcoming drug resistance, therefore, is the key to successful treatment of ovarian cancer. Dr…

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Understanding How Ovarian Cancer Spreads

Survival rates for ovarian cancer are significantly improved when disease is detected early, before cancer cells spread beyond the ovary. Therefore, therapeutic strategies that inhibit cancer cell spread should improve survival rates. Dr…

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A New Class of Drugs with Potential Against Ovarian Cancer: PARP-inhibitors

PARP-Inhibitors represent an exciting new class of drugs that are proving to be highly effective for women with hereditary ovarian cancer…

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Engineering T Cells to Augment Natural Immunity to Ovarian Cancer

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Characterizing a Key Biological Pathway in the Ovarian Cancer Microenvironment

A significant goal of ovarian cancer research is trying to understand how ovarian cancer tumors grow and spread with the aim of trying to prevent both processes. Dr…

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Tumor Blood Vessels in Ovarian Cancer Development, Diagnosis and for Treatment

Tumor blood vessels are different than normal blood vessels. Besides functioning differently than normal blood vessels, tumor blood vessels make unique proteins not made by normal blood vessels. With OCRF support, Dr…

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Reprogramming Immune Cells to Treat Ovarian Cancer

The goal of Dr. Consejo-Garcia’s project is to enhance the immune response of ovarian cancer patients to prevent recurrences and induce long-term remissions…

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Understanding the Molecular Biology of Metastasis in Ovarian Cancer

The ability of ovarian cancer cells to metastasize throughout the peritoneal cavity is primarily responsible for the high mortality rate of patients with this disease…

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Determining the Role of Estrogen in Ovarian Cancer

Women are exposed to estrogen, the female steroid hormone, throughout their reproductive lives. As natural levels of estrogen fall in menopause, some women take hormone replacement therapy containing estrogen…

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