Year: 2011

A New Approach to Treating Recurrent Ovarian Cancer and Newly Diagnosed Disease

Although most ovarian cancer tumors initially respond to chemotherapy, the cancer typically returns because the tumor becomes resistant to the drugs. Unfortunately, few treatments are available for patients with recurrent disease. Dr…

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Ovarian Cancer: A Theme Based Approach Toward Identification of Novel Diagnostic and Therapeutic Targets

The goal of this project is to characterize the genetic and molecular mechanisms that regulate epithelial ovarian cancer growth and progression and to identify biological molecules that, by modulating such processes, may have diagnostic and…

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Understanding how Ovarian Cancer Stem Cells Play a Role in Disease Progression and Drug Resistance

Most women first diagnosed with ovarian cancer usually have advanced disease. While most of these patients will initially respond to surgery and chemotherapy, relapse with drug-resistant cancer usually occurs and the women die. In his project, Dr…

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How Do Cells Near Ovarian Cancer Cells Play a Role in the Disease?

Cancer cells recruit surrounding normal cells and transform them to spur the growth and spread of tumors. Stromal cells, one type of these normal surrounding cells, provide factors to cancer cells that enable them to multiply, spread and colonize…

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Stimulating Immune Cells to Fight Ovarian Cancer

Cancer vaccines, or treatments that enhance a patient’s immune system to fight tumor cells, hold great promise as a therapy for ovarian cancer…

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Trying to Identify the Cell Responsible for Ovarian Cancer

Due to the lack of screening tools for detection of early stage ovarian cancer, most ovarian cancer is diagnosed late, when the disease has already spread in the patient’s abdomen. At a late stage, current treatments are less effective…

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Finding a Marker to Detect Early Stage Ovarian Cancer

Detection of ovarian cancer before it progresses to late stage disease is a major challenge for ovarian cancer researchers. When ovarian cancer is detected early, it has a high cure rate…

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Novel Approach to Destroy the Blood Supply that Feeds Ovarian Cancer Tumors

While most ovarian cancer patients respond to available treatments, most patients eventually experience disease progression resulting in death. Novel therapeutic strategies are therefore urgently required. Dr…

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Understanding How Ovarian Cancer Spreads

How ovarian cancer tumors progress and spread is an active area of research…

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Development of Combination Therapy with PARP-Inhibitors and Immunomodulation for BRCA1-Epithelial Ovarian Cancer

Recent studies have shown that women with ovarian cancers that result from an inherited mutation in the BRCA gene, show an excellent response to a drug called a PARP inhibitor…

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Identifying Early Events in Ovarian cancer Using a 3-D Model of Ovarian Tissues

Little is known about the earliest events and the tissues in the body that give rise to ovarian cancer. Does the cancer arise from surface cells, or epithelial cells, on the ovary, fallopian tube or both? The answer is unknown…

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What is the Relationship Between an miRNA Molecule and Resistance to Chemotherapy?

A significant problem for women with ovarian cancer is the high incidence of recurrence after chemotherapy. To help these women, researchers are trying to develop new treatments that could potentially overcome resistance…

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