Year: 2012

Functional Characterization of the Tumor Suppressor ARID1A in Ovarian Cancer

Ovarian clear cell carcinoma is a type of highly aggressive cancer that is frequently associated with endometriosis…

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Investigation of ARID3B Splicing as a Novel Therapeutic Target for Ovarian Cancer

Dr. Dahl’s lab is interested in understanding the genes that are involved in ovarian cancer progression…

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Modeling Stem Cell Origins of Epithelial Ovarian Carcinomas

Epithelial ovarian cancers (EOC) are a complex group of tumors that arise from multiple different precursor tissues, and the most common EOC subtype (high-grade serous) is now thought to originate in both the ovary and the fallopian tube…

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Targeting Signaling Networks via RNAi to Improve Therapy for Ovarian Cancer

Ovarian cancer is the second most common gynecologic malignancy, and this malignancy is the leading cause of death from gynecological cancers…

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Modeling Serous Ovarian Carcinoma Using Genetic Markers Specific for the Distal Fallopian Tube

It is critical to determine if the fallopian tubal secretory epithelial cell (FTSEC) is the cell-of-origin for the majority of high-grade serous ovarian and peritoneal carcinomas…

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Engineering Immune Cells to Better Recognize and Kill Ovarian Cancer

Ovarian cancer and other cancers are able to grow and spread in the body because the immune system cannot destroy them…

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The Role of Stromal microRNA 21 in Omental Ovarian Cancer Progression

Ovarian cancer most frequently metastasizes to the omentum, a major site of intra-abdominal fat in post-menopausal women…

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Targeting the Epigenetic Plasticity of the Platinum Response in Drug-resistant Ovarian Cancer Cells

Chemotherapy resistance is a major obstacle to the successful treatment of ovarian cancer patients. Initially responsive, most ovarian tumors become drug resistant after successive rounds of standard chemotherapy…

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Reprogramming of Ovarian Cancer Microenvironments by miRNAs

Only about 50% of the cells in ovarian cancer tumors are cancer cells. The rest are normal cells which have been “hijacked” by the cancer cells to promote tumor growth…

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The Function of ARID1A in the Transformation of Endometriosis to Ovarian Cancer

Endometriosis is a benign gynecologic condition where the cells that normally line the uterus begin to grow outside of the uterus, usually on the ovary. Women with endometriosis frequently have pain and unexplained infertility…

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Targeting Ovarian Cancer with Combination of Olaparib and Bepridil

While ovarian cancer has a typically good response to first-line chemotherapy after initial surgery, the prognosis of patients with advanced ovarian cancer remains poor. Dr…

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Diagnostic Strategies for Detection of Ovarian Cancer

The early molecular events in the development of ovarian cancers are unknown, and there are no sensitive and specific screening tests for ovarian cancer…

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