Year: 2013

Functional Analysis of Genetic Susceptibility Loci to Identify Biomarkers and Candidate Genes Associated with Ovarian Cancer Initiation, Progression and Outcome

Genetic factors can increase a woman’s chance of getting ovarian cancer; they can also affect how well a woman responds to treatment when she has been diagnosed with ovarian cancer…

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Power of Platelets in Ovarian Cancer

High platelets are particularly prevalent in women with epithelial ovarian cancer since almost 1 in 3 patients present with high platelets at diagnosis…

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The FA-BRCA Pathway and Response to Platinum and PARP Inhibitors in Ovarian, Tubal and Peritoneal Carcinomas

Ovarian carcinoma is the most deadly gynecologic cancer, causing almost 15,000 deaths annually in the U.S. Most women with ovarian cancer are treated with a combination of surgery and platinum chemotherapy…

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Role of microRNAs in the 3q26 Amplicon in Ovarian Cancer Pathophysiology and Therapy

Epithelial ovarian cancers are a complex group of tumors that arise from multiple different precursor tissues…

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Chemokine-Dependent Control of Survival in Ovarian Carcinoma

Metastasis of epithelial ovarian carcinoma is currently incurable. One way to change this situation is to develop new approaches and drugs that either alone or in combination with already existing ones are capable of fighting metastatic disease…

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A Genetically Relevant Mutant Mouse Model of Epithelial Ovarian Cancer

Ovarian clear-cell and endometrioid carcinomas are among the endometriosis-associated epithelial tumor subtypes with the lowest survival rate…

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Targeting Ovarian Cancer via Cooperative Oncogene Interactions

Ovarian cancer is the most lethal of the gynecological malignancies. Ovarian tumors can be particularly difficult to treat as they are often not responsive to the chemotherapeutics that are currently in use for the treatment of ovarian cancer…

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Evaluating ERRalpha as a Novel Therapeutic Target in Ovarian Cancer

Long-term clinical outcomes for women diagnosed with advanced epithelial ovarian cancer (EOC) have not significantly improved in the last 20 years…

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siRNA Targeting Immunosuppressive and Oncogenic Pathways in Ovarian Cancer

Cancer is the result of uncontrolled cell division. This process involves several cell types, including not only the cancer cells themselves but also the immune cells that have evolved to fight them…

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Testing the FAK and Talin Signaling Linkage in Ovarian Tumor Cell Metastasis

Ovarian cancer is the fifth leading cause of cancer-related death among women in the United States and has the highest mortality rate of all gynecologic malignancies…

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The Analysis of NEDD8-activating Enzyme Inhibitor MLN4924 on Ovarian Cancer

Ovarian cancer is the most deadly disease of the female reproductive tract and has historically been called the “silent killer.” Chemotherapy resistance and toxicity is one of the major barriers to cure ovarian cancer…

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Noval Strategy of Metabolic Targeting Ovarian Cancer: Focusing on the Tumor Hypoxia Pathway

Epithelial ovarian cancer is the deadliest gynecological cancer in women and the fifth leading cause of cancer death in women in the United States…

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