Year: 2017

Ovarian Cancer Disrupts Circadian Cortisol Rhythms

Ovarian cancer (OvCa) is a devastating disease that results in around 15,000 deaths among women in the U.S. each year…

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Mediators of Chemosensitivity and Immunotherapy Targets

Ovarian cancer is an extremely aggressive disease, that in most cases, is able to grow undetected deep within the abdominal cavity for years, until fully disseminated disease causes overt symptoms which cannot be ignored…

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Overcoming PARP Inhibitor Resistance in Ovarian Cancer

Resistance to targeted therapies is a major clinical challenge in the treatment of ovarian cancer. The majority of ovarian cancers have defects in repairing their DNA during cell division…

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Loss of H2Bub1 Rewires Glutamine Metabolism During Progression of HGSOC

Ovarian cancer is the fifth leading cause of cancer death among women in the United States…

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Targeting Dormant Ovarian Cancer Cells with Peptide Inhibitors of Autophagy

Each year in our country, more than 22,000 women develop ovarian cancer. Despite progress in surgery and chemotherapy, the disease still proves lethal in 70% of cases…

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Rational Design of Effective Multi-modal Ovarian Cancer Immunotherapy

Ovarian cancer elicits strong anti-cancer immunity, but the cancer is not eliminated…

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COL11A Is A Highly Specific Therapeutic Target in Cancer-Activated Stroma

Background: While we often think of ovarian cancer as an aggregate of cancer cells, in reality cancer cells are embedded in dense stroma which provides both structural scaffolding and gelatinous matrix that serves as a foundation of growth factors…

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Regulation of the Immune Checkpoint PD-L1 in Ovarian Cancer

The immune system is critical in the fight against cancer. The T cells of the immune system are capable of recognizing cells that have become malignant and killing them. In this way, the immune system prevents cancers from occurring…

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Integrated Roles of Epigenetics and Cell Signaling in Ovarian Cancer

Endometriosis-associated ovarian clear-cell and endometrioid carcinomas are among the epithelial tumor subtypes with the lowest survival rates…

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Chromatin Regulatory Mechanisms in Ovarian Cancer

The goal of this proposal is to understand the connection between epigenetic regulation and ovarian cancer and to begin to leverage these findings into the development of novel therapeutic strategies…

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Omental Macrophages: Drivers of Ovarian Cancer Metastasis

Identifying the microenvironmental interactions that regulate cancer metastasis is key to controlling this disease…

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Epigenetic Vulnerabilities of Ovarian Cancer Stem Cells

Ovarian epithelial cancer is a persistent cancer and does not go away with treatment. Recurrent ovarian cancer is cancer that has recurred (come back) after it has been treated…

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