Year: 2018

Understanding Epigenetic Regulation of Copy Number Gains in Ovarian Cancer

Ovarian cancer is the deadliest of all gynecologic cancers. It ranks fifth as a cause for cancer deaths among women. Up to 80% of ovarian cancer patients eventually develop resistance to standard chemotherapy with unclear mechanisms…

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Isolation and Characterization of the PAX8 Transcriptional Complex

High-grade serous carcinoma (HGSC) is the most common subtype of ovarian cancer. Many of these tumors are now believed to originate in the tips of the fallopian tubes…

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Determining the Role of ARID1A in 53BP1-mediated DNA Damage Repair

Aberrant epigenetic regulation has emerged as one of the major attributes in the pathogenesis of human cancer. Mutations of ARID1A, a core subunit of the chromatin remodeler complex, are commonly found in ovarian clear cell carcinomas (OCCC)…

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Targeting de-poly (ADP-ribosyl)ation for Ovarian Cancer Therapy

Ovarian cancer is one of the leading causes of death for women. Approximately 15% of ovarian cancer harbors the inherited mutations in BRCA1 and BRCA2. The mutation carriers of BRCA1 and BRCA2 have up to 50% lifetime risk to develop ovarian cancer…

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The Ovarian Microenvironment in Metastasis of Fallopian Tube Derived Cancer

High-grade serous ovarian cancer (HGSOC) is the most common and lethal type of ovarian cancer. It has become clear that this type of ovarian cancer can actually originate in the fallopian tube and then spread to the ovary…

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Cancer Associated Fibroblasts Hinder the B Cell Anti-Tumor Response

Stimulation of the immune system through the use of immunotherapy has proven to be an effective therapeutic to eliminate tumors…

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Reciprocal Roles of CAFs and CD4+ T Cells in Cancer Progression

The proposed study addresses the urgent need for more effective immunotherapies…

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Identifying Synthetic Lethal Targets to Mutant p53 in Development of HGSOC

Despite great improvements in our understanding of ovarian cancer biology, this disease still ranks among the top five deadliest cancers in women…

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Identifying Novel Targeted Therapies for MYC-driven Ovarian Cancer

Ovarian cancer was the leading cause of gynecologic cancer-related deaths in the US in 2016…

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Development of A Novel Syngeneic Model System for Ovarian Cancer Research

Ovarian cancer is the fifth deadliest cancer among women in developed countries. Worldwide, nearly a quarter of a million women will be diagnosed with this disease each year…

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Probing the Antagonistic Roles of 53BP1 and RAD18 in HR DNA Repair

Our DNA is constantly being damaged by, for example, UV light, ionizing radiations, or even normal biochemical processes in our body…

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Characterization of Chromatin Nanoarchitecture of Ovarian Cancer Stem Cells

Ovarian cancer is the leading cause of death from female reproductive tract cancer…

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