Year: 2019

The Role of Platelet in the Regulation of Immune Response to Ovarian Cancer

Thirty percent of patients with epithelial ovarian cancer (EOC) have elevated platelet counts…

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A Novel Targeted Therapy for Cyclin E Over Expressing Ovarian Cancers

Ovarian cancer is the sixth leading cause of cancer mortality among women in developed countries…

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DNA Repair Pathways as Targets for Therapy-Resistant Ovarian Cancer

MMR deficiency is associated with increased risk of developing ovarian cancer and is the most common cause of hereditary ovarian cancer after Brca1 and Brca2 mutations…

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Targeting Chromatin Remodeling Complex to Treat Ovarian Cancer

Epithelial ovarian cancer is the most frequent cause of gynecologic malignancy-related mortality in women in the United States; 22,240 new cases and 14,070 deaths are estimated to have occurred thus far in 2018…

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Elucidating the Role of SOX17 in HGSOC

Epithelial ovarian cancer is a deadly disease. The majority of patients with high-grade serous ovarian cancer (the most common subtype) initially respond well to a combination of surgery and platinum-based chemotherapy…

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Targeting Anti-apoptotic Proteins BCL-XL and MCL-1 in Serous Ovarian Cancer

While many ovarian cancer patients initially respond to chemotherapy, most patients ultimately develop chemotherapy-resistant disease that is difficult to treat and confers a poor prognosis…

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Utilization of Tumor-recognizing CD4+T Cells in Cancer Immunotherapy

Recently, immunotherapies have been demonstrated to induce complete remission in cancer patients…

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Precision Targeting of Altered Mitochondrial States in Ovarian Cancer

Ovarian cancer is the fifth leading cause of cancer death among women in the U.S., with an estimated 22,000 new cases and 14,000 deaths each year…

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Implantable Nanosensor for Early-Stage Detection of Ovarian Cancer

Ovarian cancer patient prognosis and quality of life are significantly affected by the failure to accurately diagnose disease at early stage, a lack of timely information regarding response to treatment, and a slow response to relapse…

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Targeting Tumor Desmoplasia to Enhance Immunotherapy

Approximately 22,400 women in the United States will be diagnosed with ovarian cancer (OvCa) in 2018, and 14,400 will die from the disease, giving OvCa the third-highest mortality:incidence ratio among all cancers…

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Developing Epigenetic Therapies for Ovarian Cancer

High-grade serous ovarian cancer (HGSOC) accounts for the majority of ovarian cancer-associated mortality…

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