Archives: Research Projects

A Machine Learning Approach to Chemotherapy-induced Remodeling of the Tumor

All patients battling ovarian cancer will undergo chemotherapy and surgery. Unfortunately, most patients will experience disease recurrence leading to secondary treatment interventions…

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Targeting MYC-HSF1 co-Amplification in High Grade Serous Ovarian Cancer

High grade serous ovarian carcinoma (OC), the most common OC epithelial subtype and fifth leading cause of mortality in women in the U.S…

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Impact of Cytomegalovirus and Inflammation on NK Cells in Ovarian Cancer

Current treatments for ovarian cancer are limited in providing prolonged disease free and overall survival outcomes. There is a critical need for novel therapeutic strategies to address these deficiencies…

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Investigating the mechanism of action of PHY34 in HGSOC

High grade serous ovarian cancer (HGSOC) is the most common and lethal form of ovarian cancer with the lowest five-year survival rate…

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Investigating the Therapeutic Potential of CRABP2 in HGSOC

Ovarian cancer remains a leading cause of cancer-related mortality in developed countries, accounting for approximately 180,000 deaths worldwide annually…

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Overcoming T Cell Exhaustion in Ovarian Cancer Tumor Microenvironment

Immunotherapy for cancer treatment presents tremendous opportunity for curing diseases such as ovarian cancer. However, there are various challenges that need to be addressed to see an effective increase in patient survival using immunotherapy…

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Ovarian Cancer Stem-like Cell Differentiation Trajectories in Single Cells

Ovarian cancer remains a disease with high mortality due to late-stage diagnoses and tumor recurrence…

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Determination of the Immunogenic Antigen Repertoire in Ovarian Cancer

Ovarian cancer is a heterogenous disease that is often managed with standard of care chemotherapy regimens, but greater than 70% of women with late-stage malignancy suffer from recurrent disease…

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Exploiting SMARCA4 Alterations for New Therapeutics in Ovarian Cancers

Ovarian cancer (OC) is the most lethal gynecological cancer…

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DIRAS3 Inhibits KRAS and Sensitizes LGSOC Cells to Anti-autophagic Therapy

Several different kinds of cancers can arise from the ovary that appear quite different under the microscope, respond to different drugs and have quite different outcomes…

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Studying the Role of BRCA1 in Regulating Heterochromatin Structure and Function in Ovarian Cancer

Project summary coming…

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Genome-Wide Profiling of 5-hydroxymethylcytosine on Cell-Free DNA

Ovarian cancer (OvCa) is the fifth most common cause of cancer related deaths among women in the United States with estimates predicting that in 2020 about 21,750 women will be diagnosed with the disease…

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