Archives: Research Projects

Understanding Mechanisms that Lead to Resistance to Platinum-based Treatments

Epithelial ovarian cancer has the highest mortality rate among gynecologic cancers. Currently, platinum and taxanes in combination are the first-line chemotherapy for epithelial ovarian cancer patients after surgical debulking…

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The Role of Genetics and Environment on Telomere Length in Ovarian Cancer

Telomeres are the repeated DNA sequences at the end of chromosomes that serve as a “biological clock…

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MicroRNAs, PI-3 kinase, and Ovarian Cancer Stem Cell Differentiation

Research in ovarian cancer has provided strong support for the “cancer stem cell” hypothesis, which proposes that a rare group of tumor cells have the unique ability to initiate and perpetuate tumor growth…

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International Ovarian Cancer Association Consortium: Finding Genetic Markers of Ovarian Cancer Using Polymorphisms

While some ovarian cancers arise in women with inherited mutations in the BRCA1 or BRCA2 genes, the genetic changes responsible for most ovarian cancers, which are not inherited, remains unknown…

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Understanding the Microenvironment Where Ovarian Cancer Grows as a Target for Treatment

Dr. Godwin focuses on the often under-explored role of the tumor microenvironment in ovarian cancer tumor growth…

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Novel Treatments for Ovarian Cancer Using siRNAs

Dr. Sood aims to develop new types of treatments for ovarian cancer using short interfering RNA or siRNA approaches. siRNA molecules are part of a natural, selective process inside cells that turn off genes…

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Cellular Microenvironment Role in Ovarian Cancer Development

The ovary is composed of an epithelium on its surface and a stroma-the inner mass consisting of several cell types. Interactions between these two compartments are crucial in epithelial ovarian cancer development…

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Characterizing the Genetic Alterations of Aggressive Ovarian Cancer

Recent advances in understanding ovarian cancer suggest that epithelial ovarian cancer can be classified into two groups: low-grade type I cancer which progress slowly from well-defined precursor lesions, and high-grade type II cancer which progress…

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The Carbohydrate Components of Cellular Molecules: A New Way to Diagnose Ovarian Cancer?

Earlier detection of ovarian cancer is the holy grail of ovarian cancer research. While many researchers focus on proteins and genes specific to ovarian cancer as possible diagnostic markers, Dr…

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Understanding the Molecular Pathways to Chemotherapy Resistance in Ovarian Cancer

Despite initial responses to surgery and chemotherapy, the majority of women with ovarian cancer ultimately die from recurrence and disease spread. Overcoming drug resistance, therefore, is the key to successful treatment of ovarian cancer. Dr…

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Understanding How Ovarian Cancer Spreads

Survival rates for ovarian cancer are significantly improved when disease is detected early, before cancer cells spread beyond the ovary. Therefore, therapeutic strategies that inhibit cancer cell spread should improve survival rates. Dr…

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A New Class of Drugs with Potential Against Ovarian Cancer: PARP-inhibitors

PARP-Inhibitors represent an exciting new class of drugs that are proving to be highly effective for women with hereditary ovarian cancer…

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