Dr. Mahdi is an assistant Professor, gynecological oncologist and physician scientist at Magee Women’s hospital and Magee Women’s Research Institute, University of Pittsburgh Medical Center. His research in ovarian cancer was recognized by awards such as V-Foundation Clinical Scholar award, GOG-F scholar award, and K12 Immuno-Oncology scholar award. His research focus is on developmental therapeutics and translational genomic/immune-oncology research in gynecologic cancer specifically ovarian cancer. He is a member of the Developmental Therapeutics, Ovarian Cancer, Translational Science and immunotherapy committees within NCTN/NRG.
As a postdoctoral fellow, he worked in an immunotherapy laboratory to create an immune vaccine using B-cells and to enhance the immune system by depleting T-regulatory cell in patients with solid tumors and leukemia. During fellowship, he worked in Dr. Eng’s laboratory to develop clinical markers to identify uterine cancer patients at risk of harboring Cowden’s syndrome. After fellowship, he received the K12 Immuno-oncology scholar award from 2018-2020 which was focused on investigating the tumor immune micro-environment in ovarian cancer. His research focus has been on developmental therapeutics to identify strategies to overcome therapy resistance and identifying genomic markers to predict response and resistance to immunotherapy and targeted therapy.