Maria Victoria Botuyan, PhD

Maria Victoria Botuyan, PhD

Dr. Botuyan received her B.S. in Chemistry from the University of the Philippines and Ph.D. in Chemistry from Purdue University. She did her postdoctoral training at the Scripps Research Institute, the Beckman Research Institute of the City of Hope, the University of Toronto, and the Mayo Clinic. She is currently a Research Scientist and an Assistant Professor at the Mayo Clinic in Rochester, MN. Dr. Botuyan is interested in understanding the molecular basis of the DNA damage response (DDR), and how defective DDR, which can lead to cancer, could be manipulated to treat the disease. As a trained biochemist and structural biologist, she has characterized the 3D structures and interactions of several DDR protein domain complexes, with some of the interactions directed by serine phosphorylation, lysine methylation, and lysine ubiquitylation. Dr. Botuyan’s current work focuses on elucidating the molecular mechanism for the antagonistic actions of DDR proteins 53BP1 and RAD18 in the homologous recombination repair of DNA double-strand breaks, and how the inhibition of these proteins by small molecules might be exploited to develop new therapeutics for ovarian cancer. Dr. Botuyan is the recipient of a US Department of Defense Ovarian Cancer Research Program award.