Dr. Shuai Wu is currently a postdoctoral fellow in the laboratory of Dr. Rugang Zhang at The Wistar Institute in Philadelphia. He received his Ph.D. degree from Shanghai Institute of biochemistry and cell biology, Chinese Academy of Science. As a Ph.D. student, he was awarded merit student of Chinese Academy of Science. With great interest in the epigenetic basis of ovarian cancers, Dr. Wu joined Dr. Rugang Zhang’s lab in 2015.
His current research focuses on synthetic lethality approaches to ARID1A mutation in ovarian clear cell and endometrioid carcinomas. In particular, Dr. Wu is interested in exploring combinatory therapeutic approaches based on synthetic lethality for ARID1A-mutated ovarian cancers. In addition, he is interested in the role of anti-apoptotic pathway in mediating resistance to synthetic lethality based therapeutic strategies in ARID1A-mutated ovarian cancers. The ultimate goal of Dr. Wu’s research is to develop the first effective therapy against ARID1A-mutated ovarian cancer, an unmet challenge in clinical management of ovarian cancer.