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OCRFA Funded Study Discovers 3 Key Genes in Prevention and ...

OCRFA Funded Study Discovers 3 Key Genes in Prevention and Treatment of BRCA1 and BRCA2 Tumors

(October 19, 2017) BRCA1 and BRCA2 are among the most frequently mutated genes in ovarian cancer. Studies conducted in the past two decades have shown that BRCA1 and BRCA2 play an essential role in protecting DNA from lesions that can lead to tumor formation. However, the factors that cause DNA lesions in BRCA1- and BRCA2-deficient … Continued

Adjuvant Chemotherapy Does Not Lead to Better Survival In C...

Adjuvant Chemotherapy Does Not Lead to Better Survival In Certain Ovarian Cancers

(October 13, 2017) The National Comprehensive Cancer Network currently recommends that early stage Ovarian Clear Cell Cancers be treated with adjuvant chemotherapy, or therapy given after the primary treatment as a way to lower the risk of recurrence. However, a retrospective study published recently in Annals of Oncology found that treating stage I endometrioid epithelial … Continued

Report from 2017 AACR Special Conference Addressing Critica...

Report from 2017 AACR Special Conference Addressing Critical Questions in Ovarian Cancer Research and Treatment

(October 13, 2017) Every other year, the American Association for Cancer Research (AACR) brings together ovarian cancer researchers from around the world to share knowledge and encourage multi-disciplinary collaboration. At this year’s conference, held October 1-4 in Pittsburgh, Pennsylvania, a focus on critical questions led to energetic discussions about ways to take information from basic … Continued

Studies Show that Current Chemotherapy Dosage is Still Best...

Studies Show that Current Chemotherapy Dosage is Still Best Option for Epithelial Ovarian Cancer

(September 15, 2017) Two studies just confirmed that, depending on one’s genetic background, the standard treatment for epithelial ovarian cancer is most likely the best option. The studies, conducted with two different populations, showed that, although the outcomes conflicted one another, the option that offered the best progression free survival was the one already used. … Continued

The Link Between Chemotherapy Resistance and a Tumor’s BRCA...

The Link Between Chemotherapy Resistance and a Tumor’s BRCA1/2 Mutations

(September 5, 2017) Researchers at the University of Pennsylvania recently uncovered a link between one’s resistance to common types of chemotherapy and one’s tumor BRCA1/2 mutation status. More specifically, they looked at both copies of the BRCA genes, one copy given by each parent. Until recently, it had been assumed that mutated BRCA gene left … Continued

Genetic Testing Rates Found to be Low in Women With A Histo...

Genetic Testing Rates Found to be Low in Women With A History of Breast or Ovarian Cancer

(August 22, 2017) The Journal of Clinical Oncology recently published a study about the unmet need of genetic testing in women with breast and ovarian cancer. Women who fit eligibility criteria from the National Comprehensive Cancer Network (NCCN) took surveys focusing on discussions about genetic testing with a health professional, being advised to have genetic … Continued

FDA Approves New Indication and Formulation for Olaparib

FDA Approves New Indication and Formulation for Olaparib

(August 21, 2017) The US Food and Drug Administration (FDA) has granted full approval to olaparib tablets (Lynparza, AstraZeneca) for use as maintenance therapy for women with recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer who have achieved a complete or partial response to platinum-based chemotherapy. This is not only a new indication for … Continued

Age When Giving Birth and Oral Contraceptives Influence One...

Age When Giving Birth and Oral Contraceptives Influence One’s Risk of Ovarian Cancer

(August 9, 2017) The International Journal of Cancer recently published an article on preliminary findings for two factors that influence one’s risk of ovarian cancer, namely the age at which a woman gives birth and the age at which she starts using oral contraceptives. The authors, including Celeste Leigh Pearce, PhD of OCRFA’s Scientific Advisory … Continued

Updated Patient Resources for Ovarian Cancer from the Natio...

Updated Patient Resources for Ovarian Cancer from the National Comprehensive Cancer Network

(July 31, 2017) The National Comprehensive Cancer Network (NCCN), has updated and published guidelines for patients with ovarian cancer. There are two parts to the resource guide: The Guidelines for Patients and Quick Guides. The NCCN Guidelines for Patients is an in depth look at topics such as testing, stages of cancer, and treatments. There … Continued

OCRFA Funded Project Has Breakthrough on Therapeutic Approa...

OCRFA Funded Project Has Breakthrough on Therapeutic Approach for Rare Ovarian Cancer

(July 27, 2017) Earlier this week, in Nature Cell Biology, researchers at The Wistar Institute published their findings about a few strategies to treat clear cell carcinoma. Clear cell is a rare form of ovarian cancer that does not usually respond well to platinum-based chemotherapy, which leaves patients with few options. In most cases of … Continued

Leading ovarian cancer organization announces 2017 honorees

Leading ovarian cancer organization announces 2017 honorees

Largest private funder of ovarian cancer research recognizes top researchers and community leaders NEW YORK — Today, Ovarian Cancer Research Alliance (OCRFA), the nation’s leading ovarian cancer research, advocacy and patient support organization, announces this year’s winners of its research and survivor awards at its annual conference. OCRFA honors two outstanding researchers for their cutting-edge … Continued

USPSTF Does Not Recommend Ovarian Cancer Screening for Gene...

USPSTF Does Not Recommend Ovarian Cancer Screening for General Population

(July 19, 2017) The United States Preventative Services Task Force (USPSTF) has once again recommended against screening for ovarian cancer in asymptomatic, average risk women. The draft statement, which was published on July 18th, does not apply to women who are positive for BRCA1 and BRCA2 genetic mutations, who have a higher risk of developing … Continued

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