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Statin Therapy and Improved Survival in Some Ovarian Cancer...

Statin Therapy and Improved Survival in Some Ovarian Cancer Patients

(September 2, 2014) New research by researchers at the University of Chicago, including OCRF grantee and Scientific Advisory Committee member Ernst Lengyel, MD, PhD, investigated whether statin use is associated with improved epithelial ovarian cancer (OvCa) survival.  The findings were published this month in PLoS One. The use of statins to lower cholesterol as a … Continued

Dietary Fat Intake and Risk of Epithelial Ovarian Cancer

Dietary Fat Intake and Risk of Epithelial Ovarian Cancer

(August 27, 2014) Recent research published in Cancer Epidemiology suggests that there is “no association with consumption of total fat, animal or plant fat, saturated fat, cholesterol, monounsaturated fat, or fatty fish and risk of invasive epithelial ovarian cancer.” An international team of researchers was interested in assessing the relationship between fat intake and risk … Continued

New Report Recommends Classifying Cancer by Genetic and Mol...

New Report Recommends Classifying Cancer by Genetic and Molecular Type

(August 21, 2014) A research network in the US proposes that cancer should be classified according to genetic and molecular features rather than by the type of tissue in which the tumor arises. While more work is needed to confirm and build on the findings, the scientists say such a system would be better for … Continued

Drug Combination Impacts Outcomes in Ovarian Cancer Patient...

Drug Combination Impacts Outcomes in Ovarian Cancer Patients without BRCA Mutations

BRCA mutations in ovarian cancer are a double-edged sword.  While BRCA gene mutation carriers have a significantly higher risk of developing ovarian cancer, BRCA gene mutation in tumors is associated with a significant increase in patient survival.  Scientists believe that this is because loss of BRCA gene expression leads to an increase tumor cell response … Continued

Epigenetic Targeting of Ovarian Cancer Stem Cells

Epigenetic Targeting of Ovarian Cancer Stem Cells

(July 29, 2014)   OCRF-funded research published earlier this month provides the first proof of principle that epigenomic strategies efficiently target ovarian cancer stem cells, which are key for treatment resistance and the major factor in therapy failures.  OCRF grantees Kenneth Nephew, PhD and Daniela Matei, MD are first and senior author of the paper, which was … Continued

Most High Risk Women Aren't Aware of Ovarian Cancer Risk

Most High Risk Women Aren't Aware of Ovarian Cancer Risk

(July 28, 2014) Research published last week in Behavioral Medicine suggests that most high-risk women (>75%) do not know their risk for ovarian cancer. Women with a documented deleterious mutation in BRCA1 or BRCA2 are at substantially elevated risk for ovarian cancer. To understand what percentage of women with high risk family histories know their … Continued

OCRF Research Sheds New Light on Ovarian Cancer Metastasis

OCRF Research Sheds New Light on Ovarian Cancer Metastasis

(July 21, 2014) According to research funded in part by OCRF, circulating tumor cells spread ovarian cancer through the bloodstream, homing in on a sheath of abdominal fatty tissue where it can grow and metastasize to other organs. This new finding, supported in part by an OCRF Program Project Development Grant to Anil Sood, MD, … Continued

OCRF Research Shows ARID1A is Tumor Suppressor Gene

OCRF Research Shows ARID1A is Tumor Suppressor Gene

(July 8, 2014) Frequent mutations in the ARID1A gene have been previously discovered in ovarian endometrioid and clear-cell cancers.  Now research supported by OCRF has provided direct evidence that it is an authentic tumor suppressor gene using a mouse model.  OCRF Ann Schreiber Mentored Investigator grantee Bin Guan, PhD is first author, and OCRF Scientific … Continued

Q&A with OCRF Grantee John Weroha, MD, PhD

Q&A with OCRF Grantee John Weroha, MD, PhD

Q&A with John Weroha, MD, PhD 2014 Liz Tilberis Early Career Award Mayo Clinic               Were you always in interested in science?  By the time I was in high school I knew I wanted to have a career in biology, but I think my interest actually started earlier.  When … Continued

No Link Between Fertility Drugs and Breast, Ovarian and Ute...

No Link Between Fertility Drugs and Breast, Ovarian and Uterine Cancers

(July 1, 2014)  There is “little evidence” that the use of conventional fertility hormones used for ovarian stimulation in the treatment of infertility increases the long-term risk of breast and gynecological cancers, according to the results of a significant 30-year follow-up study. However, the extended use of clomiphene citrate was associated with a higher risk … Continued

Palliative Care at Time of Cancer Diagnosis Improves Survival

Palliative Care at Time of Cancer Diagnosis Improves Survival

(June 25, 2014) Research presented at the annual meeting of the American Society of Clinical Oncology earlier this month suggests that palliative care delivered at the time of cancer diagnosis improves survival. A randomized trial of palliative oncology care in 207 patients with advanced cancer and their caregivers showed that the risk of death at … Continued

Gemcitabine, Carboplatin, and Bevacizumab Extend PFS

Gemcitabine, Carboplatin, and Bevacizumab Extend PFS

(June 24, 2014) Earlier this month, researchers reported results of a Phase II trial which looked at efficacy and safety of a biweekly gemcitabine, carboplatin, and bevacizumab combination in patients with platinum-sensitive recurrent ovarian, peritoneal, or tubal cancer. The results, which were published online June 5, 2014 in the journal Gynecologic Oncology, showed that biweekly … Continued

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