Comparison of Clear Cell and Serous Ovarian Cancer- Characteristics and Prognosis

(July 21, 2015) A group of Chinese researchers compared clinical characteristics and prognosis between ovarian clear cell carcinoma (CCC) and serous carcinoma (SC), and found that women with ovarian CCC presented at a younger age and early stage. Patients with ovarian CCC also had a longer time to recurrance, but they had similar overall survival compared to patients with SC. However, patients with advanced CCC had decreased survival. The findings were published this month in PLoS One.

Data from 504 Chinese women, who were treated between 1999 and 2009, was examined.  The mean age of the patients with SC was greater than of CCC patients.  Patients with CCC were more likely to be early-stage and optimally debulked. Regarding CA-125, 22% of the patients with CCC had normal values, and the level was significantly lower than in patients with SC.  More CCC patients had platinum-resistant tumors compared with platinum-sensitive disease.  The 5-year survival rate was 51.2% in the CCC group vs. 49.8% in the SC group.  Patients with advanced CCC had a statistically significant poorer overall survival (OS) compared with their SC counterparts (38.0 vs. 52.0 months). However, the advantage of improved progression-free survival (PFS) existed across all stages.

Click here to read the full abstract.

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