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The Relationship Between Cytotoxic CD8 Tumor-Infiltrating L...

The Relationship Between Cytotoxic CD8 Tumor-Infiltrating Lymphocytes and Overall Survival in High Grade Serous Ovarian Cancer

(December 11, 2017) A study by the Ovarian Tumor Tissue Analysis Consortium, published in JAMA Oncology, looked at the association between cytotoxic CD8+ tumor-infiltrating lymphocytes (TILs) and overall survival with certain types of ovarian cancer. After an immunohistochemical analysis of 5,577 patients, researchers saw a strong correlation between high levels of CD8+ TILs and longer … Continued

Research

Study Reveals Overall Survival Disparities Among Race and S...

Study Reveals Overall Survival Disparities Among Race and Stage

(December 8, 2017) The results of the CONCORD-2 study, recently published in Cancer, show a large difference in ovarian cancer survival between black women and white women, and also between stages at diagnosis. The data collected from the study, the largest of its kind, looked at 172,849 cases of ovarian cancer, over the course of … Continued

Research

Phase II Trial Points to Possible Benefits of IP Chemothera...

Phase II Trial Points to Possible Benefits of IP Chemotherapy after Neoadjuvant Therapy and Surgery

(December 4, 2017) The results of a phase II trial, which focused on stages IIB to IVA epithelial ovarian cancer, were recently published in the Annals of Oncology. The primary purpose of the six year, two stage, multicenter trial was to look at the nine month progressive disease rate when using intraperitoneal (IP) chemotherapy after … Continued

Research

Last Chance for VIP Access to Turn Up the Heat

Last Chance for VIP Access to Turn Up the Heat

Turn Up the Heat is a foodie’s paradise, featuring treats and libations from more than 50 incredible local women chefs, mixologists, and restaurateurs. Join us on Wednesday, March 7th at the Ronald Reagan Building and International Trade Center in Washington, DC to support Ovarian Cancer Research Alliance. Until December 1st, when you buy a General … Continued

Events

OCRFA Funded Research Identifies Mechanism Underlying Ovari...

OCRFA Funded Research Identifies Mechanism Underlying Ovarian Cancer Development

(November 22, 2017) A recent paper published in the Journal of Clinical Investigation reports that a subset of ovarian cancers reduce the expression of a critical gene involved in recycling the cells’ proteins, known as ubiquitin B (UBB). Silencing the expression of a closely related gene, also in the ubiquitin family, that performs an identical … Continued

OCRA News

New Research Indicates that High Grade Serous Ovarian Carci...

New Research Indicates that High Grade Serous Ovarian Carcinomas Originate in the Fallopian Tubes

(October 30, 2017) Until recently, it was thought that high-grade serous ovarian carcinomas (HGSOCs) arose from the ovarian surface epithelium, but recent data from two studies published in Nature Communications suggest that all high grade serous ovarian cancers do in fact originate in the fallopian tube. These findings have implications for ovarian cancer detection and … Continued

Research

White Blood Cells Found in High Grade Ovarian Cancer May Po...

White Blood Cells Found in High Grade Ovarian Cancer May Point to Survival Outcomes

(October 20, 2017) An international, large scale study may have found a link between high-grade ovarian cancer and a type of white blood cell known as a tumor-infiltrating lymphocyte. Recently published in JAMA Oncology, the article from the Ovarian Tumor Tissue Analysis Consortium discussed the study, which involved about 5,500 patients, 3,196 of whom had … Continued

Research

OCRFA Funded Study Discovers 3 Key Genes in Prevention and ...

OCRFA Funded Study Discovers 3 Key Genes in Prevention and Treatment of BRCA1 and BRCA2 Tumors

(October 19, 2017) BRCA1 and BRCA2 are among the most frequently mutated genes in ovarian cancer. Studies conducted in the past two decades have shown that BRCA1 and BRCA2 play an essential role in protecting DNA from lesions that can lead to tumor formation. However, the factors that cause DNA lesions in BRCA1- and BRCA2-deficient … Continued

OCRA News

Adjuvant Chemotherapy Does Not Lead to Better Survival In C...

Adjuvant Chemotherapy Does Not Lead to Better Survival In Certain Ovarian Cancers

(October 13, 2017) The National Comprehensive Cancer Network currently recommends that early stage Ovarian Clear Cell Cancers be treated with adjuvant chemotherapy, or therapy given after the primary treatment as a way to lower the risk of recurrence. However, a retrospective study published recently in Annals of Oncology found that treating stage I endometrioid epithelial … Continued

Research

Report from 2017 AACR Special Conference Addressing Critica...

Report from 2017 AACR Special Conference Addressing Critical Questions in Ovarian Cancer Research and Treatment

(October 13, 2017) Every other year, the American Association for Cancer Research (AACR) brings together ovarian cancer researchers from around the world to share knowledge and encourage multi-disciplinary collaboration. At this year’s conference, held October 1-4 in Pittsburgh, Pennsylvania, a focus on critical questions led to energetic discussions about ways to take information from basic … Continued

Research

OCRFA’s Response to Trump Administration’s Birth Cont...

OCRFA’s Response to Trump Administration’s Birth Control Coverage Rollback

(Oct. 11, 2017) Last week, the Trump Administration issued a regulation to immediately allow employers to deny insurance coverage for birth control on the basis of their own moral or religious objections, undermining the landmark benefit under the Affordable Care Act (ACA) that guarantees coverage for contraception without co-pays or cost-sharing. Audra Moran, President and … Continued

Advocacy

Studies Show that Current Chemotherapy Dosage is Still Best...

Studies Show that Current Chemotherapy Dosage is Still Best Option for Epithelial Ovarian Cancer

(September 15, 2017) Two studies just confirmed that, depending on one’s genetic background, the standard treatment for epithelial ovarian cancer is most likely the best option. The studies, conducted with two different populations, showed that, although the outcomes conflicted one another, the option that offered the best progression free survival was the one already used. … Continued

Research

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