1999 Recipient Dineo Khabele, MD

Project Summary

Dr. Khabele will use microarray-based analysis for the examination of the expression of multiple genes in cell culture specimens from patients with ovarian cancer. Using the method, Dr. Khabele hopes to identify new gene mutations in ovarian cancer and to detect differences in the gene expression among different stages of ovarian cancers, ranging from normal tissue to advanced stages of disease. Microarray analysis may make it also possible to assess prognosis based on the initial study of gene expression of a particular specimen. The findings someday may allow the discovery of new biomarkers for early diagnosis and follow-up, and the assessment of specific genetic sites for intervention and therapy.

Areas of Research:

Bio

Professor and Chair, Department of Obstetrics & Gynecology at Washington University School of Medicine in St. Louis Dineo Khabele, MD is the Mitchell & Elaine Yanow Professor and Chair of the Department of Obstetrics & Gynecology at Washington University School of Medicine in St. Louis. She is a recognized physician-scientist with extensive clinical and translational research experience in gynecologic oncology, with a focus on ovarian cancer. Dr. Khabele’s ovarian cancer research is funded by the National Institutes of Health (NIH)/National Cancer Institute (NCI). Her ovarian cancer research interests include chemotherapy resistance, DNA repair, epigenetic targets for therapy, and targeting the tumor microenvironment. She is a dedicated educator and mentor to students, residents, fellows, and faculty. She is an advocate for women’s health, women’s cancers, and health equity. Dr. Khabele is board certified in Obstetrics and Gynecology and Gynecologic Oncology and obtained undergraduate and medical degrees from Columbia College and Columbia College of Physicians and Surgeons of Columbia University in New York. She completed her residency in obstetrics and gynecology at The New York Presbyterian Hospital, Weill-Cornell University Medical Center, followed by a clinical fellowship in gynecologic oncology and post-doctoral research training in cancer biology at Albert Einstein College of Medicine and Montefiore Medical Center. She was a scholar of the Reproductive Scientist Development Program and the Amos Medical Faculty Development Program Scholar/Robert Wood Johnson Foundation.