Ovarian cancer is an abnormal process within the female human body. Through a process known as “tolerance,” the host immune system does not recognize malignant ovarian cancer cells as abnormal. The cells are tolerated by the immune system and the cancer continues to grow and metastasize in an unabated fashion. The ovarian cancer vaccine trial conducted by Dr. Irvin and his colleagues is designed to activate a woman’s immune system to the malignancy, so the immune system will seek out and destroy the malignant cells. The vaccine will be used in combination with surgery and chemotherapy.
This project was made possible by a generous grant from Johnson & Johnson.