ASCO 2015 Update
…now have treatments (PARP inhibitors, such as Lynparza) to target BRCA1 and BRCA2 mutations, scientists are not yet sure how to target other mutations present in ovarian cancer tumors. With…
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Draft USPSTF Statement Recommends Against Ovarian Cancer Screening
…high risk for the disease, either because of family or personal history, or other risk factors like BRCA1 or 2 genetic mutations. OCRF is currently working with the USPSTF on…
Study Shows 1 in 5 Women with Ovarian Cancer has Inherited Predisposition
…Some occurred in genes already known to be associated with a genetic predisposition to ovarian cancer, such as BRCA1and BRCA2, while others occurred in genes that have never been linked…
Dr. Kathryn Terry on the Genetics of Ovarian Cancer.
…are more likely to carry the BRCA1 and BRCA2 mutations that increase breast and ovarian cancer risk. Consequently, these families often have sisters, daughters, cousins, etc. with breast and/or ovarian…
Most High Risk Women Aren't Aware of Ovarian Cancer Risk
…in BRCA1 or BRCA2 are at substantially elevated risk for ovarian cancer. To understand what percentage of women with high risk family histories know their risk is elevated, researchers at…
RAD51 Mutations Confer Moderate Risk of Ovarian Cancer
…EOC and 2,772 controls from a case-control study, as well as 2,000 unaffected BRCA1/2-negative women from the U.K. Familial Ovarian Cancer Screening Study. OCRF SAC member Kunle Odunsi, MD, PhD,…
A New Generation Finds Purpose in Fundraising to Fight Ovarian Cancer
…and Elizabeth on the day Elizabeth was tested for BRCA mutations An opportunity to contribute came about when Emma started making bracelets earlier this year and a few friends expressed…
A Rogue Parakeet and a Reason for Hope
…impacted your family? Cancer does not just affect the patient; it includes family and friends. Even though I didn’t have a BRCA1 or BRCA2 mutation that could increase ovarian cancer…
USPSTF Does Not Recommend Ovarian Cancer Screening for General Population
…published on July 18th, does not apply to women who are positive for BRCA1 and BRCA2 genetic mutations, who have a higher risk of developing ovarian cancer. There are two…
Jeff Boyd, PhD, Appointed Chair of OCRF Scientific Advisory Committee
…ovarian cancer, as well as other women’s cancers. He has helped define the role of tumor suppressors and oncogenes in these malignancies, most notably the p53, BRCA1 and BRCA2 tumor…
Multimodal Study Uses Machine Learning to Improve Risk-Stratification of HGSOC
…in the TGCA-OV set. To gain insights around treatment resistance, particular attention was paid to homologous recombination-deficient (HRD) disease status, presence of BRCA1 or BRCA2 mutations, and associated response to…
Screening High-Risk Women Catches More Early Stage Ovarian Cancers
…primary recommendation for women of high risk, specifically after having children, before the age of 40 for BRCA1 carriers, and before 45 years of age for BRCA2 carriers. “Up until…