Oophorectomy Increases Breast Cancer Survival in BRCA1 Mutation Carriers
…diagnosed with stage I or II breast cancer who also tested positive for the BRCA1 mutation. Involved in the study were 676 women, 345 of whom had their ovaries removed…
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Population Screening for BRCA Mutations in Ashkenazi Jewish Women is Cost-Effective
…National Cancer Institute compared the cost-effectiveness of population-based BRCA testing with the standard FH-based approach in Ashkenazi Jewish (AJ) women. The study found that population-based screening for BRCA mutations is…
Non-BRCA Genes Associated with Breast and Ovarian Cancers Identified and Confirmed
(August 24, 2018) A recent study, published in JAMA Oncology, shed light on non-BRCA gene associations to breast and ovarian cancers. Researchers discovered new genes and confirmed previously existing evidence…
Most Women Getting BRCA Test not Getting Genetic Counseling
(October 7, 2015) A report published in JAMA Oncology shows that most commercially insured women who underwent BRCA genetic testing did not receive genetic counseling by trained genetics professionals. Lack…
New Study on BRCA Mutation in Women with Ovarian Cancer
A new study of 1,001 women with ovarian cancer found that 14% of them carried a BRCA1 or BRCA2 mutation. However, 44% of those women did not have a family…
Current Grantees
…High Fat Metastatic Niche View details for Nicola Meagher, PhD Mentored Investigator Grant Nicola Meagher, PhD The University of Sydney Equitable access to BRCA testing: an Australian national data linkage…
Hormone Replacement Therapy After Oophorectomy Is Not Shown to Increase Risk of Breast Cancer in BRCA1 Mutation Carriers
(May 4, 2018) JAMA Oncology recently published a study that looked at the risk of breast cancer in BRCA1 carriers who underwent a prophylactic bilateral salpingo-oophorectomy, a surgery that removes…
Discoverer of BRCA genes said “being ignored” helped her do her research
Last week marked the 20th year anniversary of the discovery of the BRCA1 gene by Mary-Claire King, Ph.D., an American geneticist. Dr. King, who was interviewed last week by NPR,…
Early oophorectomy cuts risk of death in BRCA mutation carriers
New research published this week suggests that women with BRCA1 mutations should have a prophylactic oophorectomy by the age of 35 to lessen their risk of developing and dying from…
Rucaparib FDA Approved for Advanced Ovarian Cancer with BRCA Mutations
…women with advanced ovarian cancer who have been treated with two or more chemotherapies and whose tumors have a specific gene mutation (deleterious BRCA) as identified by an FDA-approved companion…
Alliance Responds to Angelina Jolie's BRCA1 Announcement
Actress Angelina Jolie recently announced that she carries a mutation in the BRCA1 gene, which makes her more likely to develop breast and ovarian cancer. In the wake of that…
Hereditary Breast and Ovarian Cancer Syndrome (HBOC)
…BRCA positive.” What they mean is that a genetic test has shown that they have harmful changes in either the BRCA1 or BRCA2 gene that increase their risk of ovarian or…