Search Results for “brca” - Page 5 - Ovarian Cancer Research Alliance

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Simon Gayther, PhD

...development and characterization of human avatars of fallopian tube epithelium (FTE) differentiated from induced pluripotent stem cell (iPSC) models of women carrying germline BRCA1/BRCA2 mutations can identify novel molecular mechanisms...

Oct 12, 2012

Andrew Berchuck, MD, Chair of OCRF’s Scientific Advisory Committee, discusses the role of genetics in ovarian cancer

...predisposition to the disease. About half of these cases are related to the BRCA1 and BRCA2 genes, which also strongly increase breast cancer risk. The risk of ovarian cancer may...

Dec 14, 2012

Meet Mindy Gray: Wife, Mother, Sister, Philanthropist, and OCRF Board Member

...to ensure that families affected by BRCA 1 and BRCA 2 gene mutations can get the support and genetic counseling that they need and understand their lifetime risk of developing...

Jan 14, 2022

OCRA-Funded Research Points to Potential for Predicting Ovarian Cancer

...more than 70% of epithelial ovarian cancers. This subtype is also associated with BRCA1 and BRCA2 genetic mutations, which are inherited changes to the genes on chromosomes 17 and 13,...

Jasmine Plummer, PhD

...BRCA1 mutations develop OC, hence BRCA1 dysfunction is not the only genetic event required to drive tumor formation. All high grade serous OC tumors also require another genetic hit in...

Jun 13, 2013

Press Release: Ovarian Cancer Advocates Praise Supreme Court Decision on Gene Patents

...test for those mutations called BRCAnalysis that costs approximately $3,300. The BRCA1 and BRCA2 mutations are heritable mutations, meaning that a person may inherit them through their mother or father....

Feb 3, 2017

Rucaparib Extends PFS in Ovarian Cancer

...with BRCA wild-type and loss of heterozygosity high, or LOH high, and the third group with BRCA wild-type and LOH low. Each group was treated with oral rucaparib twice per...

Oct 13, 2021

Study Finds Germline Ovarian Cancer Mutations Occur Equally in Black and White Patients

...and of those, all had high-grade carcinoma. BRCA1 (13.7%) and BRCA2 (7.8%) mutations were the most common pathogenic germline mutations identified, and the study also found one instance of RAD51D...

Apr 1, 2014

Updates from the 2014 Society for Gynecologic Oncology Annual Meeting

...Recent research suggests that between 11 and 18% of ovarian cancers arise because of genetic mutation in one of 13 genes, including the well-recognized BRCA1 and BRCA2, but also the...

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