Sohrab Shah, PhD

Chief, Computational Oncology Dept. of Epidemiology & Biostatistics
Director, Halvorsen Center for Computational Oncology
Nicholls-Biondi Endowed Chair in Computational Oncology
Memorial Sloan Kettering Cancer Center

Professor, Physical Biosciences and Systems Biology Department
Weill Cornell Medical College

Dr. Shah is the Chief of the Computational Oncology service and was awarded the Nicholls-Biondi Endowed Chair in Computational Oncology at Memorial Sloan Kettering Cancer Center in 2018. He is also appointed as Professor in the Physical Biosciences and Systems Biology Department of Weill-Cornell Medical College. In 2024 he was appointed as Director of the newly established Halvorsen Center for Computational Oncology. He oversees the academic research of ten PI-led laboratories dedicated to computational research in cancer biology and translational science. Dr Shah’s research in ovarian cancer focuses on understanding the principles and processes of cancer evolution. Focusing on high grade serous ovarian cancer, his laboratory has uncovered the genomic properties of mutational signatures, tumor evolution and intraperitoneal spread. More recently at MSK, he established MSK SPECTRUM, a program for studying ovarian cancer evolution through single cell approaches where his group identified immunological pathways to immune evasion that are linked to mutational processes such as HRD and breakage fusion bridge structural variants. His laboratory also focuses on the development of experimental and computational methods for single cell whole genome sequencing and genotype-phenotype associations at single cell resolution which has led to recent advances in studying the role of whole genome doubling in ovarian cancer evolution. His work in ovarian cancer has been published in the New England Journal of Medicine, Nature, Cell and Nature Genetics.