Archives: Research Projects

Targeting multifactorial immune evasion mechanisms in ovarian cancer

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Tackling PARPi sensitivity in HRP and HRD cells

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Strategies to Exploit Genetic Alterations in Clear-Cell Ovarian Cancer

Ovarian cancer is the sixth leading cause of cancer death among women in developed countries. Clear cell ovarian cancer (CCOC) is a subtype of ovarian cancer that is mostly resistant to chemotherapy with limited treatment options…

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Chemopreventative Targets in BRCA1 Carrier Models with P53 Lesions

Gail Baird Foundation Research Grant  Ovarian cancer (OC) ranks among the top five deadliest cancers in women and its low survival rate has not improved significantly in the last 40 years…

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Targeting Chromobox 2 to Overcome Macrophage-induced Immune Suppression

High grade serous ovarian carcinoma (HGSOC) is the deadliest gynecologic malignancy, thus there is an urgent need to define novel treatment options and improve patient outcomes…

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BRCA-deficient Ovarian Cancer and IFITM3: a New Power Couple

More than 14,000 patients in the United States die of ovarian cancer each year, making this cancer the fifth leading cause of cancer death among women in the United States…

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Probing How RAD18 and BARD1 Antagonize 53BP1 in HR DNA Repair

Our DNA is constantly being damaged by, for example, UV light, chemicals or even normal processes in our cells. The damage can take many forms, one of the most serious being breaks in both strands of the DNA (or DSBs for double-strand breaks)…

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Inferring Mutational Processes and Patient Stratification From Standard-of-Care Clinical Imaging

Women with high grade serous ovarian cancer (HGSOC) represent 70% of all ovarian cancers and suffer high morbidities and poor response to standard of care treatment. The five year survival rate after diagnosis is <50%…

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Cancer-derived Exosomal miRNAs Modulate Ovarian Tumor Microenvironment

Epithelial ovarian cancer (EOC) is the leading cause of gynecologic cancer-related death in the United States. Annually, 21,000 women in the United States are diagnosed with EOC and approximately 14,000 women die from it…

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The Role of Ferroptosis in the Metastatic Ovarian Cancer

We urgently need to identify new treatment approaches that can effectively reduce the burden of recurrent metastatic OVCA…

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Role of Macrophage-secreted BIGH3 in Tumor Immunity

Ovarian cancer (OvCa) is the deadliest US gynecologic malignancy with a clear need for novel therapeutic approaches…

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Re-engaging the Anti-tumor Immune Response Against Ovarian Cancer

Ovarian cancer is the fifth leading cause of cancer-related death for women in the United States. High-grade serous ovarian cancer (HGSC) is the most lethal with 70% of patients succumbing to their disease within five years of diagnosis…

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