Archives: Research Projects

Systems Approach for PARP-based Novel Combination Therapy in Ovarian Cancer

Ovarian cancer is a leading cause of death from gynecologic malignancies with an overall survival rate of less than 40%. One of the most popular approaches for treating ovarian cancer is targeted therapy by a drug called PARP inhibitor…

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The Migratory Precursor and Serous Carcinogenesis

High-grade serous ovarian carcinoma (HGSOC) accounts for 70% of ovarian cancers and is responsible for most of the 14,000 ovarian cancer deaths in the United States each year…

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CD122-Selective IL-2 Complexes as Novel Ovarian Cancer Therapy

Although immunotherapies have achieved enormous success in multiple types of cancer, ovarian cancer is not one of them…

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Exploring PROTAC-Mediated Degradation of BRD4 in Ovarian Cancer

The BET bromodomain protein BRD4 represents as a promising drug target for High-grade Serous Ovarian Carcinoma (HGSOC) due to its role in promoting cancer cell growth and survival…

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The Fate and Function of Adipocytes in Ovarian Cancer Metastasis

Ovarian cancer (OvCa) is the most lethal cancer of the female reproductive system due to the fact that it is most often diagnosed after it has already metastasized throughout the abdomen…

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Characterizing a Novel Checkpoint Axis in High-Grade Serous Ovarian Cancer

Advanced stage diagnosis is common in high-grade serous ovarian cancer (HGSOC) primarily due to ineffective screening…

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Identifying the Cell of Origin for Ovarian High Grade Serous Carcinoma

The most common and most lethal type of ovarian cancer is high grade serous carcinoma (HGSC)…

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Phase II Trial of Gemcitabine+ATR Inhibitor: Translational Studies

Ovarian cancer (EOC) remains the most lethal gynecologic malignancy, of which high grade serous EOC (HGSOC) represents 70% of cases…

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Targeting ER Stress Pathway in CARM1-Expressing Ovarian Cancer

Epithelial ovarian cancer (EOC) remains the deadliest gynecological cancer in the United States. EOC is comprised of multiple separate diseases…

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Sensitizing Ovarian Cancer to Immunotherapies

Recent advances in immunotherapy hold the promise to one day permit a cure for ovarian cancer…

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Epigenetic Causes of Acquired Resistance of Anti-VEGF Therapy

The major reported cause of ovarian cancer mortality is resistance to conventional chemotherapies which in turn promotes cancer metastasis…

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Oncogenic Consequences of Altered SWI/SNF-RNA Interactions in SCCOHT

Ovarian cancer is the fifth leading cause of cancer-related deaths in women. There are about 20,000 new cases per year and only 46% of those women survive five years…

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