Archives: Research Projects

Rational Design of Effective Multi-modal Ovarian Cancer Immunotherapy

Ovarian cancer elicits strong anti-cancer immunity, but the cancer is not eliminated…

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COL11A Is A Highly Specific Therapeutic Target in Cancer-Activated Stroma

Background: While we often think of ovarian cancer as an aggregate of cancer cells, in reality cancer cells are embedded in dense stroma which provides both structural scaffolding and gelatinous matrix that serves as a foundation of growth factors…

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Regulation of the Immune Checkpoint PD-L1 in Ovarian Cancer

The immune system is critical in the fight against cancer. The T cells of the immune system are capable of recognizing cells that have become malignant and killing them. In this way, the immune system prevents cancers from occurring…

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Integrated Roles of Epigenetics and Cell Signaling in Ovarian Cancer

Endometriosis-associated ovarian clear-cell and endometrioid carcinomas are among the epithelial tumor subtypes with the lowest survival rates…

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Chromatin Regulatory Mechanisms in Ovarian Cancer

The goal of this proposal is to understand the connection between epigenetic regulation and ovarian cancer and to begin to leverage these findings into the development of novel therapeutic strategies…

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Omental Macrophages: Drivers of Ovarian Cancer Metastasis

Identifying the microenvironmental interactions that regulate cancer metastasis is key to controlling this disease…

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Epigenetic Vulnerabilities of Ovarian Cancer Stem Cells

Ovarian epithelial cancer is a persistent cancer and does not go away with treatment. Recurrent ovarian cancer is cancer that has recurred (come back) after it has been treated…

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Drugs Inducing Necroptotic Cell Death As A New Strategy for High Grade Serous Ovarian Cancer

We recently demonstrated that chemotherapy resistant ovarian cancer stem-like cells (CSC) can be identified by a protein activity known as ALDH…

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Systematic Discovery of LncRNA Interactome in Epithelial Ovarian Cancer

Ovarian cancers (OCs) are highly aggressive malignancies and cause more deaths than any other cancers of the female reproductive system. Survival rates for OCs are very poor: for advanced disease only ~30% of patients survive beyond 5 years…

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Development of Targeted Therapies for Recurrent Ovarian Cancer

The mortality rates in many major forms of cancer have been reduced over the past decade. However, the mortality rate for ovarian cancer has not been significantly improved…

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EZH2 Determines PARPi Resistance and Fork Stabilization in Ovarian Tumors

Epithelial ovarian cancers (EOCs) are late-diagnosed and lethal tumors. A high percentage of EOCs initially respond to current therapies but eventually develop resistance. This greatly reduces patient survival…

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Rational Immunity to Improve Survival Following Standard-of-care Chemo

Ovarian cancer is the leading cause of death among gynecologic malignancies, and dramatic improvements in overall survival remaining wanting…

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