Researchers in the UK have identified a gene in mice that, if faulty, may increase the chance of developing a rare type of ovarian cancer. The findings were published in the journal Nature. The gene, known as Helq, helps repair damage to DNA that happens when it is copied as cells multiply. If the gene is missing or … Continued
An index created at The University of Texas MD Anderson Cancer Center in Houston, based on protein biomarkers was able to discriminate between women at high risk and low risk for ovarian cancer recurrence, in a recent analysis. Such information can be used to help improve the treatment and, eventually, the prognosis of patients with ovarian … Continued
The Washington Post explores new options for young women going through cancer treatment who want to know about their options for having children after treatment. The article looks at emerging methods and ways to approach the conversation with your doctor. Read the article here.
Building on previously presented work, researchers at M.D. Anderson Cancer Center in Houston have published new findings that show that evaluating the change of CA-125 over time shows promise as a screening tool for early-stage ovarian cancer. OCRF grantees Karen Lu, MD and Robert Bast, MD were first and senior author on the paper, which … Continued
The Petersen family was inspired to educate the world about small cell ovarian cancer while their daughter and sister Stephanie was undergoing treatment for the disease. “The first thing they said to us was, ‘Don’t look on the internet—you won’t find anything about small cell ovarian cancer,’ ” recalls Maren Petersen. Discouraged by the lack … Continued
In a review article published online in Oncogene on August 12, OCRF-funded researchers provide a comprehensive review of pre-clinical models used in ovarian cancer research. The authors, including OCRF grantees Ernst Lengyel, Daniela Matei, Ken Nephew, and Joanna Burdette, explore current experimental models and reflect on the strengths and weaknesses for each method. In addition, … Continued
Two dogs at the University of Pennsylvania’s Penn Vet Working Dog Center are learning how to smell tissue that is in early stages of ovarian cancer. The dogs have been able to smell the cancerous tissue 100% of the time. The dogs are part of an interdisciplinary research project to help scientists discover a chemical … Continued
Researchers in Austria investigated whether the time interval from surgery to start of chemotherapy has an impact on clinical outcome in patients with advanced serous ovarian cancer. Data from 191 patients with stage III or IV ovarian cancer who underwent surgery followed by platinum-based chemotherapy were analysed. The results, which were published in Gynecologic Oncology on … Continued
Alicia Baines was inspired to start Promises of Hope by the people in her community: “I recognized that my community is in need,” she recalls. “People are afraid to talk about cancer. It’s not until someone passes away that they realize they probably should have done more.” Promises of Hope is dedicated to serving Prince … Continued
Dr. Coleman, a member of the Alliance’s Scientific and Medical Advisory Board, conducted an interview on ovarian cancer therapies for the Cancer Network. He discussed the heterogeneity of ovarian cancer, angiogenesis inhibitors and new drugs in the pipeline. The full interview can be found here
Research published online last week in Nature Communications suggests that some of the cell lines most frequently used to study high-grade serous ovarian cancer (HGSOC) may not be the best. OCRF grantee and SAC member Douglas Levine, MD was one of the authors of the paper. Cell lines derived from tumor tissue are the most … Continued
In an article published last week in The Lancet, an international group of investigators examined whether ovarian cancer tumors’ expression of the progesterone receptor (PR) and estrogen receptor (ER) was associated with survival in various subtypes of ovarian cancer. To date, few biomarkers of ovarian cancer prognosis have been established. The study, which included 2,933 women, … Continued
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