Ovarian Cancer Risk and BRCA1 Methylation
(January 31, 2018) A study published in the Annals of Internal Medicine explains that researchers now believe that the methylation of normal BRCA1 gene promotion, not solely BRCA1 mutation, is…
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Study Finds BRCA Mutation Boosts Ovarian Cancer Survival
…the BRCA2 gene, the research showed. “BRCA1 carriers had a more favorable survival than noncarriers, which improved slightly after additional adjustment for stage, grade, histology, and age at diagnosis. BRCA2…
USPSTF Releases Draft Statement on Risk Assessment for BRCA-Related Cancer
…associated with an increased risk for potentially harmful mutations in breast cancer susceptibility genes (BRCA1 or BRCA2). Women with a positive screen should receive genetic counseling and, if indicated after counseling, BRCA…
BRCA Mutations Confer Risk, Even in Absence of Family History
…family history of the disease, 6 were found to have mutations in BRCA1 andBRCA2. Six of the 59 cases without family history were also found to have BRCA1/2 germline mutations,…
New Study Clarifies BRCA Mutations in Ovarian Cancer, Encourages Testing
…should be offered BRCA1/2 mutation testing. Researchers from the Peter MacCallum Cancer Centre in East Melbourne, Australia, screened 1,001 women with ovarian cancer to investigate the impact of germ-line BRCA1…
Ten-year Survival Not Associated with BRCA Mutation Status
…mutation status and extent of residual disease post-surgery. Results showed that by 10-years of follow-up, 43% of non-carriers, 57% of BRCA1 mutation carriers and 69% of BRCA2 mutation carriers had…
The Link Between Chemotherapy Resistance and a Tumor’s BRCA1/2 Mutations
…looked at both copies of the BRCA genes, one copy given by each parent. Until recently, it had been assumed that mutated BRCA gene left the non-mutated gene defunct, which…
BRCA1/2 Mutations and 10 year Survival in Ovarian Cancer
(January 22, 2015) In a study published in Clinical Cancer Research, researchers analyzed the effect of germline mutations in BRCA1 and BRCA2 on mortality in ovarian cancer patients up to…
Supreme Court Strikes Down BRCA Gene Patents
…et al. v. Myriad Genetics, the court considered the validity of patents held by the Utah-based company Myriad Genetics for the BRCA1 and BRCA2 genes, which when mutated are associated…
Big Strides Made in Identifying More BRCA1 Mutations
…of breast and ovarian cancers. Although the most common BRCA1 and BRCA2 mutations are already known to increase risk, there are thousands of variants of those genes that were previously…
No Long-Term Survival Benefit for BRCA Mutation Carriers
…investigate long-term survival (10 years post diagnosis) in BRCA mutation carriers. Their results show that “for women with invasive ovarian cancer, the short-term survival advantage of carrying a BRCA1 or…
BRCA Cancer Risk Differs With Type and Location of Mutations
(April 15, 2015) Doctors have long recognized that women with mutations in two particular genes – BRCA1 and BRCA2 – have a higher risk of breast and ovarian cancer. Now…