Search Results for “brca” - Page 7 - Ovarian Cancer Research Alliance

Oct 11, 2016

Niraparib Significantly Improves Outcome of Ovarian Cancer Patients

...and without germline BRCA mutations. In a randomized, double-blind, phase III trial of over 550 women both with and without germline BRCA mutations, researchers found that patients receiving niraparib once...

Jan 8, 2016

OCRF Research Finds Inherited Mutations in 18% with Ovarian Cancer

...BRCA2. Learn more. Of the 1,915 patients surveyed, eighteen percent carried a gene mutation known to be associated with ovarian cancer, such as BRCA1 and BRCA2. Learn more. 19 19...

Priyanka Verma, PhD

2023 Early Career Investigator Grant Washington University in St. Louis Project Summary Mutations in genes involved in the BReast CAncer (BRCA)-dependent DNA repair pathway represent approximately 50% of high-grade serous...

Maria Victoria Botuyan, PhD

...53BP1 – regulate HR DNA repair. BRCA1-BARD1 and RAD18 activate HR DNA repair while 53BP1 inactivates HR DNA repair. A correct balance of BRCA1-BARD1, RAD18 and 53BP1 is needed for...

Oct 12, 2012

Q&A with Sarah Adams, M.D., 2011 Liz Tilberis Awardee

...research. SA: Women with ovarian cancers that result from an inherited mutation in the BRCA gene show excellent response to a drug called a PARP inhibitor. The drug specifically kills...

Dec 17, 2015

Team Twedt: Taking on Ovarian Cancer, One Ironman at a Time

...genetic makeup – a BRCA gene mutation. Dawn and Jamie A Tough Decision Her sister and mother had it, and both had been diagnosed with cancer – first her mother...

Aug 21, 2015

Multi-gene Testing for Ovarian Cancer Risk is Clinically Useful

...(which looks for mutations in many genes), identifies more people with cancer risk related gene mutations than screening for BRCA1 and 2 alone. Importantly, identifying these additional gene mutations provides...

Jul 15, 2021

The Overview: July 2021

...tumor cells in laboratory cell lines and tumor models with BRCA1 or BRCA2 genetic mutations. Read on to discover how it has been found to be effective even in tumors that have...

Sep 11, 2015

Teaming Up Against Ovarian Cancer

...cancers. Specifically, we are targeting the cell’s repair mechanism, which mends breaks in the DNA and corrects mistakes. In cancer cells, defects in the BRCA1 or BRCA2 genes cause one...

Sep 10, 2015

Teaming Up Against Ovarian Cancer

...in the DNA and corrects mistakes. In cancer cells, defects in the BRCA1 or BRCA2 genes cause one of the repair mechanisms, or pathways, to lose function. In the absence...

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Search Results for: "brca"

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Niraparib Significantly Improves Outcome of Ovarian Cancer Patients

OCRF Research Finds Inherited Mutations in 18% with Ovarian Cancer

Priyanka Verma, PhD

Maria Victoria Botuyan, PhD

Q&A with Sarah Adams, M.D., 2011 Liz Tilberis Awardee

Team Twedt: Taking on Ovarian Cancer, One Ironman at a Time

Multi-gene Testing for Ovarian Cancer Risk is Clinically Useful

The Overview: July 2021

Teaming Up Against Ovarian Cancer

Teaming Up Against Ovarian Cancer

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