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Thales Nepomuceno, PhD

Dr. Thales Nepomuceno obtained his B.Sc. degree in biology at the Federal Institute of Rio de Janeiro (Brazil) in 2014. He also holds an M.Sc. (2016) and a Ph.D. (2020) degree in Oncology from the Brazilian National Cancer Institute. Throughout his education, he focused his attention on BRCA1, with a particular interest in the mechanisms of DNA damage repair…

OCRA Awards Nearly $6.5 Million in Ovarian Cancer Research Grants

More breakthroughs are on the horizon, as OCRA has awarded grants to 22 dedicated scientists at 15 prestigious medical institutions to enable future ovarian cancer discoveries. With this funding, OCRA grantees aim to answer questions that have vexed the scientific community, building on our collective knowledge and identifying new opportunities for ovarian cancer prevention and treatment…

Probing How RAD18 and BARD1 Antagonize 53BP1 in HR DNA Repair

Our DNA is constantly being damaged by, for example, UV light, chemicals or even normal processes in our cells. The damage can take many forms, one of the most serious being breaks in both strands of the DNA (or DSBs for double-strand breaks). Our cells repair DSBs by different processes. The most accurate is called homologous recombination or HR…

Ovarian Cancer Research Discoveries Made by OCRA Grantees in 2021

We’re pleased to report that thanks to your support, OCRA grantees made breathtaking strides toward better understanding, preventing and treating ovarian cancer this year. Discovered unique genetic switches associated with ovarian tumors, and identified 3 potential drug targets for aggressive ovarian cancers. Revealed how certain cells drive immunotherapy resistance, and show that targeting a signaling pathway in these cells improved tumor response to immunotherapy…

Study Finds Germline Ovarian Cancer Mutations Occur Equally in Black and White Patients

A recent study has shed more light on the demographics of hereditary ovarian cancer, and provides further data to suggest an urgent need for increased genetic counseling for potentially high-risk Black women, as well as increased genetic testing in Black ovarian cancer patients. The study, which took place over the course of 20 years and was recently published in the journal Gynecologic Oncology…

High-Grade Serous Carcinoma

High-grade serous carcinoma is the most common type of ovarian cancer, accounting for approximately 75% of epithelial ovarian cancers. Because it is the most common type of ovarian cancer, it is often the default type that’s referenced in discussions of ovarian cancer, unless another type is specified. Up until recently, it was thought that ovarian cancers develop in the epithelium (the cells lining the surface) of the ovaries…

The Overview: July 2021

Sultry summer days can make anyone feel lazy and daydream of faraway places. But at OCRA, we’re working as hard as ever to fulfill our dream of a day when no one need fear an ovarian cancer diagnosis. Check out all that’s happening and discover ways that you can get involved. RESEARCH Many of us have heard of BRCA mutations…

What is Lynch Syndrome?

Inherited gene mutations, such as BRCA 1 and BRCA 2, can increase the risk of developing ovarian cancer as well as uterine (endometrial) cancer. Some of these mutations, which affect MLH1, MSH2, MSH6, PMS2 and EPCAM genes, can cause Lynch Syndrome. This disorder is also called hereditary non-polyposis colorectal cancer (HNPCC) and, as its name suggests…

Can You Get Ovarian Cancer At Any Age?

Ovarian cancer is the seventh most commonly occurring cancer in women worldwide, and causes more deaths than any other type of female reproductive cancer. In the United States, it ranks fifth in cancer deaths among women. Certain risk factors can increase the chances of an individual developing ovarian cancer, one being age. Though the cancer risk increases as a person gets older…

Highlights: 2021 Virtual Annual Meeting of the Society of Gynecologic Oncology (SGO)

2021 SGO Virtual Meeting Themes Annie Ellis and Kathleen Maxian This year’s Society of Gynecologic Oncology annual meeting was held virtually, with most sessions held March 19 to 21, 2021. The majority of sessions included pre-recorded abstract presentations followed by dynamic and engaging live Q&A. In addition to the latest research in gynecologic cancers highlighted below…

OCRA Awards Prizes in Ovarian Cancer Research

Each year, OCRA honors individuals doing important and notable work in the ovarian cancer field with a research prize to help propel their future discoveries. Individuals are selected by members of OCRA's Scientific Advisory Committee. Dr. Sarah Adams Awarded Liz Tilberis Research Prize for Outstanding Early Career Investigators The Liz Tilberis Research Prize is awarded to an individual who has used prior OCRA funding to impact the field of ovarian cancer research…

Anup Singh, PhD

Dr. Anup Kumar Singh is currently a postdoctoral fellow in the laboratory of Anjana Rao at the La Jolla Institute for Immunology in San Diego, California. His research mainly focuses on understanding the molecular basis for alterations in chromatin landscapes and its pathogenic consequences like malignancy. Dr. Singh obtained his undergraduate degree in Bioengineering from Bundelkhand University…

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Search Results for brca