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Ie-Ming Shih, PhD

Searching for Two Kinds of Cures | Meet a Scientist

Dr. Ie-Ming Shih Ie-Ming Shih, MD, PhD is on a quest to better understand the human condition. He is a pathologist who studies human tissue to learn more about the origins of ovarian cancer; a Distinguished Professor (Endowed Chair) of Gynecologic Pathology who directs that research program at the Johns Hopkins University School of Medicine; the co-director of the Women’s Malignancy Group at the Sidney Kimmel Comprehensive Cancer Center at Hopkins…

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Multimodal Study Uses Machine Learning to Improve Risk-Stratification of HGSOC

A recent study published in Nature Cancer talks about harnessing the power of machine learning to help predict prognosis and response to treatment for those with high-grade serous ovarian cancer (HGSOC). The study is co-authored by OCRA grantees Sohrab Shah, PhD, of Memorial Sloan Kettering Cancer Center – a two-time OCRA grant recipient, most recently of OCRA’s Collaborative Research Development Grant in collaboration with Microsoft AI for Health – and Dmitriy Zamarin…

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Endometrial Cancer (Uterine Cancer)

Endometrial cancer is the most common gynecologic cancer. It develops from the inner lining of the uterus, and is commonly referred to as uterine cancer. What is Endometrial Cancer? In order to better understand endometrial cancer, it can be helpful to learn about the different layers that make up the uterus. The uterus is a hollow organ that is approximately the size and shape of a pear…

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What is Ovarian Cancer?

Cancer is a disease in which some of the body’s cells begin to divide without stopping, and spread into surrounding tissue.  Ovarian cancers are a group of diseases that affect the ovaries. The ovary is made up of three types of cells. Epithelial cells cover the surface of the ovary.  Cancers originating from these cells are the most common type of ovarian cancer…

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PARP Inhibitors and Ovarian Cancer

Over the past decade, a new class of drugs called PARP inhibitors have been approved by the Food and Drug Administration (FDA) for use in ovarian cancer. Three FDA-approved PARP inhibitors — as well as others that are still under investigation — have offered hope for patients and clinicians in their quest to cure ovarian cancer…

Science Lab

Highlights: 2022 Annual Meeting of the Society of Gynecologic Oncology (SGO)

Annie Ellis Submitted by ovarian cancer survivor Annie Ellis, OCRA Research Advocate and Scientific Advisory Committee member This year’s SGO annual meeting was held in Phoenix, Arizona from March 18-21. Approximately 2,100 medical professionals attended in person with several hundred more attending virtually to learn the latest on gynecologic cancers. By now, you may have seen professional coverage of and tweets about this meeting…

doctor in office

How is Ovarian Cancer Diagnosed?

If a doctor suspects ovarian cancer, they may perform tests such as a pelvic exam, ultrasound, CT scan, or CA-125 blood test to learn more. Surgery is the only way to make a definitive diagnosis of ovarian cancer. Understanding Symptoms and Diagnosis Before going down the path of diagnosis, it’s important to understand that symptoms are not always present with ovarian cancer…

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New Research Shows Cervical Cells May Hold Key to Predicting Ovarian Cancer Risk

Cervical cell samples that are routinely collected as part of Pap smears may hold promise for predicting the risk of ovarian and other cancers, according to recent findings published as two separate papers in Nature — one focused on ovarian cancer and the other on breast cancer. The researchers studied cervical samples collected at 15 different health centers in Europe from approximately 3,000 women — some with ovarian cancer…

OCRA-Funded Research Points to Potential for Predicting Ovarian Cancer

New study findings not only reveal where the most common ovarian cancer subtype originates in certain patients, but also point to the future possibility of being able to predict who will get the disease. The research, published in Cell Reports, was led by Clive N. Svendsen, PhD, of Cedars-Sinai Medical Center and OCRA’s Scientific Advisory Committee member Beth Y…

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Hereditary Breast and Ovarian Cancer Syndrome (HBOC)

Hereditary breast and ovarian cancer syndrome, known as HBOC, refers to a predisposition to develop cancer that is passed down through the generations of a family. HBOC is inherited in the form of a harmful mutation, or change, in a gene. Having one of these mutations increases the chances of developing ovarian cancer. Most commonly, mutations in the genes BRCA1 and BRCA2 are associated with HBOC…