Search Results for “brca” | Page 7

What is Ovarian Cancer?

Cancer is a disease in which some of the body’s cells begin to divide without stopping, and spread into surrounding tissue. Ovarian cancers are a group of diseases that affect the ovaries. The ovary is made up of three types of cells. Epithelial cells cover the surface of the ovary. Cancers originating from these cells are the most common type of ovarian cancer…

PARP Inhibitors and Ovarian Cancer

Over the past decade, a new class of drugs called PARP inhibitors have been approved by the Food and Drug Administration (FDA) for use in ovarian cancer. Three FDA-approved PARP inhibitors — as well as others that are still under investigation — have offered hope for patients and clinicians in their quest to cure ovarian cancer…

Highlights: 2022 Annual Meeting of the Society of Gynecologic Oncology (SGO)

Annie Ellis Submitted by ovarian cancer survivor Annie Ellis, OCRA Research Advocate and Scientific Advisory Committee member This year’s SGO annual meeting was held in Phoenix, Arizona from March 18-21. Approximately 2,100 medical professionals attended in person with several hundred more attending virtually to learn the latest on gynecologic cancers. By now, you may have seen professional coverage of and tweets about this meeting…

How is Ovarian Cancer Diagnosed?

If a doctor suspects ovarian cancer, they may perform tests such as a pelvic exam, ultrasound, CT scan, or CA-125 blood test to learn more. Surgery is the only way to make a definitive diagnosis of ovarian cancer. Understanding Symptoms and Diagnosis Before going down the path of diagnosis, it’s important to understand that symptoms are not always present with ovarian cancer…

New Research Shows Cervical Cells May Hold Key to Predicting Ovarian Cancer Risk

Cervical cell samples that are routinely collected as part of Pap smears may hold promise for predicting the risk of ovarian and other cancers, according to recent findings published as two separate papers in Nature — one focused on ovarian cancer and the other on breast cancer. The researchers studied cervical samples collected at 15 different health centers in Europe from approximately 3,000 women — some with ovarian cancer…

OCRA-Funded Research Points to Potential for Predicting Ovarian Cancer

New study findings not only reveal where the most common ovarian cancer subtype originates in certain patients, but also point to the future possibility of being able to predict who will get the disease. The research, published in Cell Reports, was led by Clive N. Svendsen, PhD, of Cedars-Sinai Medical Center and OCRA’s Scientific Advisory Committee member Beth Y…

Hereditary Breast and Ovarian Cancer Syndrome (HBOC)

Hereditary breast and ovarian cancer syndrome, known as HBOC, refers to a predisposition to develop cancer that is passed down through the generations of a family. HBOC is inherited in the form of a harmful mutation, or change, in a gene. Having one of these mutations increases the chances of developing ovarian cancer. Most commonly, mutations in the genes BRCA1 and BRCA2 are associated with HBOC…

Thales Nepomuceno, PhD

Dr. Thales Nepomuceno obtained his B.Sc. degree in biology at the Federal Institute of Rio de Janeiro (Brazil) in 2014. He also holds an M.Sc. (2016) and a Ph.D. (2020) degree in Oncology from the Brazilian National Cancer Institute. Throughout his education, he focused his attention on BRCA1, with a particular interest in the mechanisms of DNA damage repair…

OCRA Awards Nearly $6.5 Million in Ovarian Cancer Research Grants

More breakthroughs are on the horizon, as OCRA has awarded grants to 22 dedicated scientists at 15 prestigious medical institutions to enable future ovarian cancer discoveries. With this funding, OCRA grantees aim to answer questions that have vexed the scientific community, building on our collective knowledge and identifying new opportunities for ovarian cancer prevention and treatment…

Probing How RAD18 and BARD1 Antagonize 53BP1 in HR DNA Repair

Our DNA is constantly being damaged by, for example, UV light, chemicals or even normal processes in our cells. The damage can take many forms, one of the most serious being breaks in both strands of the DNA (or DSBs for double-strand breaks). Our cells repair DSBs by different processes. The most accurate is called homologous recombination or HR…

Ovarian Cancer Research Discoveries Made by OCRA Grantees in 2021

We’re pleased to report that thanks to your support, OCRA grantees made breathtaking strides toward better understanding, preventing and treating ovarian cancer this year. Discovered unique genetic switches associated with ovarian tumors, and identified 3 potential drug targets for aggressive ovarian cancers. Revealed how certain cells drive immunotherapy resistance, and show that targeting a signaling pathway in these cells improved tumor response to immunotherapy…

Study Finds Germline Ovarian Cancer Mutations Occur Equally in Black and White Patients

A recent study has shed more light on the demographics of hereditary ovarian cancer, and provides further data to suggest an urgent need for increased genetic counseling for potentially high-risk Black women, as well as increased genetic testing in Black ovarian cancer patients. The study, which took place over the course of 20 years and was recently published in the journal Gynecologic Oncology…

For Patients

Research

Advocacy

How to Help

Search Results for brca