Dmitriy Zamarin, MD, PhD is an Assistant Attending Physician and Translational Research Director in the Gynecologic Medical Oncology Service at the Memorial Sloan Kettering Cancer Center. Dr. Zamarin graduated Summa Cum Laude with a BS degree in Biology from Manhattan College. He obtained his MD and PhD degrees from the Mount Sinai School of Medicine in New York, where he was focused on the studies of influenza virus pathogenesis under the mentorship of Dr. Peter Palese. He completed residency in Internal Medicine at the Mount Sinai Hospital in New York and fellowship in Hematology/Oncology at the Memorial Sloan Kettering Cancer Center, where he worked under the mentorship of Dr. James Allison and Dr. Jedd Wolchok, studying the mechanisms of response and resistance to immunomodulatory antibody therapy and virus-based therapeutics.
Dr. Zamarin is currently a principal investigator and a translational chair on several institutional and cooperative group clinical trials exploring novel immunotherapy combinations in gynecologic cancers. In the laboratory, his research is focused on understanding of the mechanisms by which ovarian cancers are recognized by the immune system and on identification of biomarkers predictive of response and resistance to immunotherapy. His laboratory in addition uses mouse models to explore the mechanisms of tumor-immune system interactions and to develop novel therapeutics, with particular focus on oncolytic viruses and targeted therapies. His current work is focusing on understanding how alterations in SWI/SNF chromatin remodeling components affect tumor recognition by the immune system and the use of epigenetic drugs to promote tumor immunogenicity. For his work, Dr. Zamarin has received numerous awards, including Damon Runyon Foundation Fellowship Award, Young Investigator Award from the Conquer Cancer Foundation, Judith Liebenthal Robinson Ovarian Cancer Foundation Award, GOG Foundation Scholar Investigator Award, and the Ovarian Cancer Academy Grant from the Department of Defense.