Nicole James, PhD

Dr. Nicole James is an Assistant Professor (Research) of Obstetrics and Gynecology at the Warren Alpert Medical School of Brown University and Women and Infants Hospital of Rhode Island. She received her BS in Biology from Providence College and obtained her Ph.D. in Pharmaceutical Sciences from the University of Rhode Island. Her postdoctoral fellowship was completed at Women and Infants Hospital of Rhode Island where she was subsequently appointed as research faculty. Since her time as a graduate student Dr. James’s research has been primarily focused on ovarian cancer. Her early pre-doctoral work evaluated human epididymis protein 4 (HE4) ‘s role in ovarian cancer pathogenesis and immune evasion, while her postdoctoral studies focused on translational immune profiling of high grade serous ovarian cancer patient tissue to uncover novel immune prognostic markers indicative of improved outcomes. Dr. James’s lab’s current research centers upon elucidating the role that amphiregulin (AREG) plays in modulating the ovarian tumor immune microenvironment and targeting AREG in combination with standard of care chemotherapy and clinically available immunotherapies to improve high grade serous ovarian cancer patient clinical outcomes.