Dr. Marmorstein obtained his Ph.D. in Chemistry from the University of Chicago and, following a postdoctoral fellowship at Harvard University, joined the faculty at The Wistar Institute in 1994. In 2013, Dr. Marmorstein relocated to the Perelman School of Medicine at the University of Pennsylvania where he is currently a Professor in the Department of Biochemistry and Biophysics and Investigator in the Abramson Family Cancer Research Institute (AFCRI). Dr. Marmorstein also holds adjunct appointments at the Wistar Institute and the Department of Chemistry at the University of Pennsylvania.
Dr. Marmorstein’s laboratory studies the molecular mechanisms of protein post- and co-translational modification with a particular focus on protein acetylation and phosphorylation and chromatin regulation. The laboratory uses a broad range of molecular, biochemical and biophysical research tools centered on macromolecular structure determination. The laboratory is particularly interested in gene regulatory proteins and their upstream signaling kinases that are aberrantly regulated in cancer, melanoma and ovarian cancer in particular, and other age-related disorders. The laboratory also uses high-throughput small molecule screening and structure-based design strategies towards the development of protein-specific small-molecule probes to be used to further interrogate protein function and for development into therapeutic agents.