(December 3, 2019) The origins of high grade serous ovarian carcinoma (HGSOC) is a debated topic in the scientific community. Prior research has suggested the cancer arises from the fallopian tube epithelium, and other evidence supports the theory that ovarian surface epithelium cells are the site of origin. OCRA-funded research by Shuang Zhang, PhD, from … Continued
Friends, The day before Thanksgiving is a busy one for me, and I imagine, for you too. But before I turn my attention to holiday prep, I wanted to sit down and write this email to you, and everyone who supports OCRA. THANK YOU. It’s hard to overstate the deep gratitude I feel when I … Continued
(November 25, 2019) This Giving Tuesday, we need your help to make a big impact. For the 22,000 American women diagnosed with ovarian cancer every year, and the 200,000 living with this disease, we’re asking you to join us in #GivingTeal. Here’s how you can help. Be an OCRA Holiday Hero Spread the word and … Continued
(November 13, 2019) A study recently published in Nature Communications and led by OCRA grantee Dr. Rugang Zhang showed that the ARID1A protein plays a fundamental role in ensuring correct chromosome segregation when the cells divide. Specifically, ARID1A controls expression of another protein called STAG1 that is required to keep chromosome ends together. When ARID1A … Continued
That’s a wrap on #OCRAStyleLab, and what an evening it was for ovarian cancer awareness! (November 6, 2019) Our sincere gratitude to our amazing hosts Maggie Gyllenhaal and Kate Mara, the fabulous En Vogue, media partner InStyle and all the incredible supporters who joined us for this meaningful night to shine a spotlight on ovarian … Continued
In an effort to further understand disease initiation and progression, OCRA grantee Dr. Sumegha Mitra, along with colleagues at Indiana University, conducted research which revealed key changes in gene expression occurring during the initiation and early metastasis of ovarian cancer. Dr. Mitra and colleagues identified targets and pathways which can be explored in the future … Continued
(October 28, 2019) Newk’s Cares, the ovarian cancer awareness movement and national campaign founded by fast-casual restaurant Newk’s Eatery, has reached monumental heights! Celebrating its sixth year, Newk’s Cares raised more than $400,000 in September—their largest total to date to support OCRA—and has now surpassed $1.4M raised for ovarian cancer research! Newk’s Cares honors the … Continued
We need your help to strengthen critical gynecologic cancer education and awareness programs. (October 16, 2019) Recently, Rep. Rosa DeLauro (D-CT)—leader of the Congressional Ovarian Cancer Caucus and an ovarian cancer survivor herself—introduced HR 4560, legislation to reauthorize Johanna’s Law, also known as The Gynecologic Cancer Education and Awareness Act. Johanna’s Law supports a variety … Continued
(September 19, 2019) While harnessing the immune system has resulted in strong responses for a subset of cancer patients, the majority of patients have remained unresponsive to this approach. In order to enable ovarian cancer patients to benefit from immunotherapy, Dr. Michael Goldberg’s research sought to understand how standard-of-care chemotherapy influences immune cells around the … Continued
It’s important for everyone to know the symptoms and risk factors for ovarian cancer. If you or someone you know are experiencing any of the symptoms listed below, take notice and take it seriously—and also know that their presence does not automatically indicate ovarian cancer. Take our ovarian cancer quiz: Want to deepen your understanding … Continued
(September 10, 2019) Ovarian clear-cell carcinoma is an aggressive form of ovarian cancer. Endometriosis is derived from the uterine endometrium and is a known risk factor for ovarian clear-cell carcinoma. Evidence supports ovarian clear-cell origins in the uterine endometrium. It has been known for years that co-occurring cellular mutations are observed in ovarian clear-cell carcinoma, … Continued
(September 5, 2019) OCRA funded investigator Dmitriy Zamarin, MD, PhD contributed to a study that provides an intriguing hypothesis that mutation in genes like SMARCA4 may improve tumor recognition by the immune system. The body’s immune system plays a major role in controlling tumor growth. Specialized immune cells called T-cells identify cancer cells as “foreign” … Continued
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