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Search Results for brca

Omental Macrophages: Drivers of Ovarian Cancer Metastasis

Identifying the microenvironmental interactions that regulate cancer metastasis is key to controlling this disease. We have shown that immune cell-containing structures, known as milky spots in the omentum are required for ovarian cancer colonization of peritoneal adipose. Organ-specific colonization might be governed in part by interactions between chemokine receptors on cancer cells and chemokine gradients in target organs…

Some Fallopian Tube Lesions Represent Ovarian Cancer Metastases, Not Precursor Lesions

(Dec. 21, 2016) Research published recently in Cancer Discovery suggests that cells in the fallopian tube previously thought to be precursors to high grade serous ovarian cancer may sometimes be cells that have metastasized and implanted into the fallopian tube. The research was conducted by a team at the University of Chicago under the guidance of OCRFA Scientific Advisory Committee member and former grantee Dr…

Niraparib Significantly Improves Outcome of Ovarian Cancer Patients

(October 11, 2016) According to research published this month in the New England Journal of Medicine, the PARP inhibitor niraparib improves progression free survival in recurrent, platinum-sensitive women both with and without germline BRCA mutations. In a randomized, double-blind, phase III trial of over 550 women both with and without germline BRCA mutations…

Stand Up to Cancer Update Webinar

OCRFA and Dr. Elizabeth Swisher spoke about the exciting progress being made by the Stand Up to Cancer Ovarian Cancer Dream Team! The SU2C Ovarian Cancer Dream Team, funded by OCRFA and NOCC, got to work on year ago. Dr. Swisher, a gynecologic oncologist at the University of Washington and co-leader of the Dream Team, updated us on the progress the Team is making on this important and ambitious research project…

Melinda Yates, PhD

Melinda S. Yates, Ph.D. is currently a Postdoctoral Fellow in the Department of Gynecologic Oncology and Reproductive Medicine at The University of Texas MD Anderson Cancer Center in Houston, Texas. Dr. Yates completed her Bachelor of Science degree in Chemistry at Purdue University (West Lafayette, Indiana) and her Ph.D. in Pharmacology and Molecular Sciences at Johns Hopkins University School of Medicine (Baltimore…

Hui Shen, PhD

Dr. Hui Shen joined Van Andel Research Institute’s Center for Epigenetics as an assistant professor in 2014. Prior to joining VARI, she completed her graduate studies at University of Southern California, where she received training in both cancer biology and biostatistics. She was a recipient of numerous fellowships there, including the Provost’s Ph.D. Fellowship; an NIH Cellular…

Barbara Stulken Norquist, MD

Dr. Barbara Stulken Norquist received a Bachelor of Science degree in Biology from the University of Washington in 1999.  She then graduated with honors from the University of Washington School of Medicine in 2004, and went on to a residency there in obstetrics and gynecology (2004 – 2008).  Following residency, she completed a fellowship in gynecologic oncology (2008 – 2012)…

Mo Li, PhD

Mo Li, PhD is a research fellow in the Department of Internal Medicine at the University of Michigan. After obtaining his B.S. degree from Northeastern Agriculture University in China in 2005, he finished his PhD at Chinese Academy of Sciences in 2010. After that, he joined Dr. Xiaochun Yu’s lab in University of Michigan to study DNA damage and repair in tumorigenesis both in vitro and in vivo…

Zeina Kais, PhD

Zeina Kais Ph.D. is postdoctoral fellow in the lab of Dr. Alan D’Andrea at Dana Farber Cancer institute in Boston, MA. Dr. Kais earned her B.S. and M.S. from the American University of Beirut (Beirut, Lebanon) and has recently completed her Ph.D. in Molecular Cellular and Developmental Biology under the guidance of Dr. Jeffrey Parvin at the Ohio State University (Columbus…

Ryan B. Jensen, PhD

Dr. Ryan Jensen is an Assistant Professor in the Department of Therapeutic Radiology at the Yale School of Medicine. He joined the faculty at Yale in 2011 and recently obtained a secondary appointment in the Department of Pathology. After graduating from U.C. Berkeley with a degree in Molecular and Cell Biology, Ryan was employed by the biotechnology company…

Simon Gayther headshot

Simon Gayther, PhD

Simon Gayther, PhD, received his postgraduate degree in Cancer Genetics from University College London (UCL) in the UK. He undertook his postgraduate training at Cambridge University, UK, before returning to UCL as Faculty in 2004. He moved to the USA in 2010, first to the University of Southern California as Full Professor and then to Cedars Sinai Medical Center in 2015 where he is currently Professor in the Department of Biomedical Sciences…

Wael El Shamy, PhD

Associate Professor of Radiation Oncology and Pathlogy Director, Molecular Cancer Therapeutics Program PhD, Molecular Neurobiology, 1998, The Royal Karolinska for Medical Research, Stockholm, Sweden Postdoc, Cancer Biology, 1999-2002, Dana Farber Cancer Institute, Boston, MA, Instructor 2002-06, Medicine, Harvard Medical School, Boston, MA, Research interests Translational Research in breast and ovarian cancer Molecular biology study of BRCA1-IRIS and Geminin in breast and ovarian cancer metastases Development of drugs and/or drug regimens to target breast and ovarian cancer metastases Research synopsis Recently…