Search Results for “brca” - Page 14 - Ovarian Cancer Research Alliance

Nov 17, 2009

Jeff Boyd, PhD, Appointed Chair of OCRF Scientific Advisory Committee

...ovarian cancer, as well as other women’s cancers. He has helped define the role of tumor suppressors and oncogenes in these malignancies, most notably the p53, BRCA1 and BRCA2 tumor...

Jul 15, 2022

Multimodal Study Uses Machine Learning to Improve Risk-Stratification of HGSOC

...in the TGCA-OV set. To gain insights around treatment resistance, particular attention was paid to homologous recombination-deficient (HRD) disease status, presence of BRCA1 or BRCA2 mutations, and associated response to...

Mar 15, 2017

Screening High-Risk Women Catches More Early Stage Ovarian Cancers

...primary recommendation for women of high risk, specifically after having children, before the age of 40 for BRCA1 carriers, and before 45 years of age for BRCA2 carriers. “Up until...

Nov 14, 2012

Study Reveals New Mechanism of Action for PARP Inhibitors

...in their ability to kill cancer cells. PARP inhibitors are a class of drugs that have shown promising results against ovarian cancer in women with BRCA1 and BRCA2 gene mutations....

Apr 12, 2022

Highlights: 2022 Annual Meeting of the Society of Gynecologic Oncology (SGO)

...cancers respond to particular treatments or better tolerate treatment at a lower starting dose (predictive biomarkers). Biomarkers can be mutation carrier status (BRCA1 or 2+), molecular characteristics of tumors (HRD,...

Dec 20, 2013

Partner Member Profile: Hope for Heather

...in honor of Rebecca Hafner, who lost her life to ovarian cancer. They partner with breast cancer organizations to hold combined events, raising awareness about the BRCA1 and BRCA2 inherited...

Nov 13, 2018

For Some, Statin Use Can Decrease the Risk of Ovarian Cancer

...seen in women who were BRCA1 or BRCA2 positive or women who were premenopausal. 11 on For Some, Statin Use Can Decrease the Risk of Ovarian Cancer The best outcomes...

Nicola Meagher, PhD

...in BRCA genes and homologous recombination deficiency) is a critical access step in increasing treatment options. The tests can also identify whether relatives have an increased risk of ovarian cancer,...

Hao Nie, PhD

...improve efficacy and/or overcome resistance to PARP inhibitors in EOCs with homologous recombination deficiency such as those caused by BRCA mutations. This grant was made possible in part by generous...

Dec 21, 2018

OCRA Funded Research Delves Deeper into How PARPi Work

...including OCRA grantee Ursula Matulonis, MD, treated BRCA-1 deficient tumors with olaparib, a PARPi, and found that it began both a natural and medically induced antitumor process that was STING...

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