Current Grantees
…Apoptotic Vulnerabilities in Ovarian Cancer Simon Gayther, PhD, Cedars-Sinai Medical Center iPSC Modeling of Ovarian Cancers in BRCA1 and 2 Mutation Carriers 2022 Grant Recipients Jen-Tsan Chi, MD, PhD, Duke…
Search Results
OCRFA Research Finds New Gene Mutation Spurs Cancer Growth
…understand to have a role similar to those of BRCA1 and BRCA2. BRCA1 and BRCA2 are well known genes that, when working, help with DNA damage repair, which protects the…
Dr. Andrew Berchuck, Chair of OCRF’s Scientific Advisory Committee, discusses the role of genetics in ovarian cancer
…disease. About half of these cases are related to the BRCA1 and BRCA2 genes, which also strongly increase breast cancer risk. The risk of ovarian cancer may be as high…
OCRA-Funded Research Points to Potential for Predicting Ovarian Cancer
…more than 70% of epithelial ovarian cancers. This subtype is also associated with BRCA1 and BRCA2 genetic mutations, which are inherited changes to the genes on chromosomes 17 and 13,…
Rucaparib Extends PFS in Ovarian Cancer
…with BRCA wild-type and loss of heterozygosity high, or LOH high, and the third group with BRCA wild-type and LOH low. Each group was treated with oral rucaparib twice per…
Press Release: Ovarian Cancer Advocates Praise Supreme Court Decision on Gene Patents
…test for those mutations called BRCAnalysis that costs approximately $3,300. The BRCA1 and BRCA2 mutations are heritable mutations, meaning that a person may inherit them through their mother or father….
Study Finds Germline Ovarian Cancer Mutations Occur Equally in Black and White Patients
…and of those, all had high-grade carcinoma. BRCA1 (13.7%) and BRCA2 (7.8%) mutations were the most common pathogenic germline mutations identified, and the study also found one instance of RAD51D…
Meet Mindy Gray: Wife, Mother, Sister, Philanthropist, and OCRF Board Member
…to ensure that families affected by BRCA 1 and BRCA 2 gene mutations can get the support and genetic counseling that they need and understand their lifetime risk of developing…
Updates from the 2014 Society for Gynecologic Oncology Annual Meeting
…Recent research suggests that between 11 and 18% of ovarian cancers arise because of genetic mutation in one of 13 genes, including the well-recognized BRCA1 and BRCA2, but also the…
Prevention & Risk
…these can guide you in taking preventive actions. Talk to your doctor if you are concerned about your risk of developing ovarian cancer. Genetic Risk Factors BRCA1 and BRCA2 Genetic…
2022 Breakthroughs in Ovarian Cancer Research and Treatment
…cancer. The most common type of mutations linked to ovarian cancer are ones that occur in the BRCA genes associated with DNA repair: BRCA1 (BReast CAncer gene 1) and BRCA2…
Genetic Counseling and Testing by Oncologists Feasible for Ovarian Cancer Patients
…BRCA mutations was worthwhile, as was the ENGAGE testing guidelines. The study concluded that oncologist led BRCA mutation testing via these guidelines was well received and could offer a faster,…