Search Results for “brca” - Page 8 - Ovarian Cancer Research Alliance

May 7, 2021

Highlights: 2021 Virtual Annual Meeting of the Society of Gynecologic Oncology (SGO)

...United Kingdom, presented “Rucaparib vs chemotherapy in patients with advanced, relapsed ovarian cancer and a deleterious BRCA mutation: efficacy and safety from ARIEL4, a randomized phase 3 study.” Watch “Rucaparib vs....

Apr 18, 2014

SGO and AACR Research Round-Up

...and ovarian cancer While having a BRCA1 or BRCA2 mutation puts women at high risk of developing breast or ovarian cancer, not all women with the mutation end up developing...

Jul 5, 2013

Family History of Breast Cancer but no Genetic Mutation Does Not Raise Risk of Ovarian Cancer

...a breast cancer family history clinic found that women with a BRCA2 mutation had a 17-times higher risk of developing ovarian cancer than average, and women with a BRCA1 mutation...

Aug 17, 2011

New Genetic Mutation Increases Risk of Ovarian Cancer

...on August 7th. Much like the BRCA1 and BRCA2 mutations, which were discovered in the 1990s and which also increase a woman’s risk for ovarian cancer, those who carry this...

Jul 9, 2013

After Angelina: What Do You Need to Know About Ovarian and Breast Cancer Risk?

...opt for testing to determine whether they carry genetic mutations such as BRCA1, BRCA2 and Lynch syndrome—all of which increase the risk of ovarian cancer. Women who know they have...

Jan 30, 2017

OCRFA Funded Research Studies DNA Repair in Ovarian Cancer Cells

...patients. It has been suggested that EMSY amplification may cause suppression on DNA damage repair in a similar manner as in BRCA1 and BRCA2 ovarian cancer patients. Researchers from both...

Michelle Swift, PhD

...BRCA1/BARD1-mediated ubiquitination of anti-resection complexes modulates DNA end resection, replication fork stability, and therapeutic responses to PARP inhibitors in BRCA1-mutated cancers. Combining proteomics, genome editing, and single-molecule approaches, I aim...

Christina Curtin, MD

2026 Mentored Investigator Grant Memorial Sloan Kettering Cancer Center Project Summary PARP inhibitor (PARPi) therapy has improved survival in high-grade serous ovarian cancer (HGSOC), especially in patients with BRCA1 and...

Richard Adeyemi, DVM, PhD

...lead to cancer. Certain patients inherit mutations in some of these critical genes, predisposing them to cancer. Two particular genes, BRCA1 and BRCA2, have been shown to be mutated often...

Feb 7, 2023

OCRA Awards $7 Million in Research Grants for 2023

...Cancer Center, “Synthetic Lethality of the Protexin and BRCA Complexes in Ovarian Cancer” Brooke Howitt, MD, Stanford University, “Identifying the Cell of Origin for High Grade Serous Carcinoma” Xiaowen Hu,...

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