Facing Down Four Recurrences and Finding Strength in Community
…taking letrozole and I’ve been in remission since! Do you have a genetic mutation associated with ovarian cancer? I am BRCA2 positive. My daughters are also BRCA2 positive, and they…
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New Ovarian Cancer PSA Features President Barack Obama’s Sister and Late Mother
…our family history, it made sense for Barack and for me to get tested for the BRCA gene mutation, which can indicate risk for ovarian and breast cancer. Thankfully, we…
Press Release: Nearly Half of Women With Ovarian Cancer Are Not Receiving Critical Genetic Testing
…particularly in identifying BRCA mutations and other genetic markers that guide treatment with precision therapies such as PARP inhibitors. Key findings of the OCRA analysis show that only 52% of…
Supreme Court to Hear Gene Patent Case
The Supreme Court of the United States will hear arguments in a case seeking to invalidate the patents on the BRCA1 and BRCA2 mutations. The patent-holder, Myriad Laboratories, owns patents…
Ovarian Cancer Research Discoveries Made by OCRA Grantees in 2021
…models with BRCA1 or BRCA2 genetic mutations, and is effective even in tumors that have become resistant to PARP inhibitors. Found that a combination of CDK9 inhibition and PP2A activation…
OCRF Research Identifies Six New Susceptibility Loci for Ovarian Cancer
…million genetic variants with epithelial ovarian cancer risk and found six additional susceptibility regions, bringing the total to 18. The variants identified have a less dramatic impact than BRCA1 or…
Ovarian Cancer Research Alliance Awards Two Prizes Recognizing Exceptional Researchers
…to advance innovative treatment approaches for ovarian cancers involving mutations in the BRCA1 and BRCA2 genes. Dr. Verma’s independent lab integrates several cutting-edge genomics and molecular biology tools to study…
OCRA Awards Nearly $6.5 Million in Ovarian Cancer Research Grants
…DC, “Targeting Chromobox 2 to overcome macrophage-induced immune suppression” Sammy Ferri-Borgogno, PhD, University of Texas M.D. Anderson Cancer Center, “BRCA-deficient ovarian cancer and IFITM3: a new “power couple” Livnat Jerby,…
Women with Medicare Found to Have Low Genetic Testing Rates
…2009 and diagnosed with breast cancer, ovarian cancer, or both. Within this population of 718 women, 92 of them were eligible for BRCA1 and BRCA2 testing but only eight of…
Searching for Two Kinds of Cures | Meet a Scientist
…PARP inhibitors, and even how genetic predispositions, such as BRCA1 and BRCA2 mutations, can change the trajectory of treatment. “Our goal to these two approaches,” Ie-Ming said, “is to convert…
ASCO 2015 Update
…now have treatments (PARP inhibitors, such as Lynparza) to target BRCA1 and BRCA2 mutations, scientists are not yet sure how to target other mutations present in ovarian cancer tumors. With…
Draft USPSTF Statement Recommends Against Ovarian Cancer Screening
…high risk for the disease, either because of family or personal history, or other risk factors like BRCA1 or 2 genetic mutations. OCRF is currently working with the USPSTF on…